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Rockville, Md. (August 29, 2019)—Physiologists and mathematicians will explore how mathematical models and imaging tools can sharpen the focus on physiological problems related to the body’s smallest blood vessels (microcirculation) at the upcoming American Physiological Society (APS) Conference: Interface of Mathematical Models and Experimental Biology: Role of the Microvasculature in Scottsdale, Ariz.

Technological advances in microvascular imaging “prompt reconsideration of the traditional organ physiology of the brain, muscle, heart, kidney and retina,” said conference co-organizer Alan M. Weinstein, MD, of the Weill Medical College of Cornell in New York. New technologies, including nanoparticle delivery systems and the use of theoretical models, “brings these topics to the cutting-edge of modern therapeutics,” Weinstein added.

The dual goals of the meeting, according to conference co-organizer Thomas Pannabecker, PhD, MBA, of the University of Arizona, Tucson, are identifying “physiological processes that would benefit from advanced computational analyses and [promoting] innovative collaborations between life science researchers and mathematicians who focus on physiological and pathophysiological studies.”

The program will include research-based sessions, abstract-driven presentations and poster sessions.

Program Highlights

Wednesday, September 11

Keynote Lecture: Using mathematical models to understand what we observe: From the microscope to the telescope
Speaker: Fitz-Roy Curry, PhD, University of California, Davis

Thursday, September 12

Symposium 1: Flow in microvascular networks
Chair: Tim Secomb, PhD, University of Arizona

Speakers:

“Nonlinearity in microvessel networks: Multiple solutions and spontaneous oscillations”
Russell Carr, PhD, University of New Hampshire

“Measurement and modelling of the coronary circulation: Experiment to computation”
Nicolas Smith, PhD, University of Auckland, New Zealand

“High-fidelity computational modeling of blood flow in physiologically realistic microvascular networks with fully-resolved erythrocyte deformation”
Prosenjit Bagchi, PhD, Rutgers University, New Brunswick, N.J.

“One size fails to fit all: Sex influences the modeling of flux from microvascular networks”
Virginia Huxley, PhD, University of Missouri

Symposium 2: Oxygen transport to tissue
Chairs: Jefferson Frisbee, PhD, University of Western Ontario, Canada; Andrew Marquis, University of Michigan

Speakers:

“Multi-scale modeling of skeletal muscle oxygen transport using arteriolar and venular networks reconstructed from experimental data”
Dan Goldman, PhD, University of Western Ontario, Canada

“Effect of pulmonary flow heterogeneity on oxygen uptake and delivery”
Tuhin Roy, MD, PhD, Mayo Clinic, Rochester, Minn.

“A multi-scale computational model of rat ventilation-perfusion matching”
Andrew Marquis, University of Michigan

“Muscle oxygen transport in health and disease: Innovative approaches, novel insights”
Daniel Hirai, PhD, Purdue University, West Lafayette, Ind.

Symposium 3: Myocardial microcirculation
Chairs: Dan Beard, PhD, University of Michigan; Christine Lauren Sy, University of Auckland, New Zealand

Speakers:

“Multi-scale modeling of supply-demand matching in myocardial oxygen delivery”
Brian Carlson, PhD, University of Michigan

“Towards a coronary microscope: Insights into the microvasculature through the lens of macro-hemodynamics”
Jonathan Mynard, PhD, Murdoch Children’s Research Institute, Australia

“Imaging coronary vasculature in cleared rat ventricle”
Christine Lauren Sy, University of Auckland, New Zealand

“Central role of the microcirculation in the etiology of heart disease”
David Gutterman, MD, Medical College of Wisconsin

Trainee Career Workshop: Careers in theoretical modeling and quantitative analysis of physiological systems
Chair: Paola Causin, PhD, University of Milan, Italy

Speakers:

“Navigating biological research as an early-career mathematician”
Marissa Renady, PhD, University of Michigan

Microvasculature and how I got here”
Adebowale Adebiyi, PhD, University of Tennessee

Friday, September 14

Symposium 4: Structural adaptation and angiogenesis in microcirculatory pathways
Chairs: Shayn Pierce-Cottler, PhD, University of Virginia; Owen Richfield, Tulane University, New Orleans

Speakers:

“Agent-based modeling of multi-cell niches in health and disease”
Shayn Pierce-Cottler, PhD, University of Virginia

“Glomerular capillary shear stress and hoop stress are significantly elevated in 5/6-nephrectomy: a modeling study”
Owen Richfield, Tulane University, New Orleans

“Mathematical models of non-drug therapies in angiogenesis”
Feilim Mac Gabhann, PhD, Johns Hopkins University, Baltimore

“A systems biology view for discovering cell dynamics during microvascular network growth”
Walter Murfee, PhD, University of Florida

Symposium 5: Cancer tissue microcirculation
Chair: Daniel Heller, PhD, Weill Medical College of Cornell, New York

Speakers:

“Multiscale modeling of bloodflow in the human vasculature”
Peter Balogh, PhD, Duke University, Durham, N.C.

“Emerging mechanistic biomarkers of cancer chemo-radiation and immunotherapy from mathematical bio-physics”
Vittorio Christini, PhD, University of Texas

“Image-based systems biology of the microvasculature in cancer”
Arvind Pathak, PhD, Johns Hopkins University, Baltimore

“Mechanobiological control of vascular function”
Lance Munn, PhD, Harvard University, Cambridge, Mass.

Symposium 6: Renal microcirculation
Chair: Anita Layton, PhD, University of Waterloo, Canada

Speakers:

“Renal oxygenation during diuresis”
Bruce Gardiner, PhD, Murdoch University, Australia

“Triple whammy: Anti-hypertensive drugs, non-steroidal anti-inflammatory agents and acute kidney injury”
Jessica Leete, Duke University, Durham, N.C.

“Renal microcirculation from structure to dynamics”
Dmitry Postov, PhD, Boston University

“Pericytes protect against renal ischemia-reperfusion injury, via sex-specific mechanism”
Jennifer Sullivan, PhD, Augusta University, Ga.

Saturday, September 14

Symposium 7: Retinal microcirculation
Chairs: Julia Arciero, PhD, Indiana University and Purdue University, Indianapolis; Lucia Carichino, PhD, Rochester Institute of Technology, Rochester, N.Y.

Speakers:

“Ocular blood flow: A delicate balance of pressures”
Giovanna Guidoboni, PhD, University of Missouri

“Modeling blood flow regulation and oxygen transport in the retinal microcirculation”
Brendan Fry, PhD, Metropolitan State University, Denver

“Modeling the effect of retinal microvasculature on ocular hemodynamics”
Lucia Carichino, PhD, Rochester Institute of Technology, Rochester, N.Y.

“Understanding risk factors in glaucoma using mathematical modeling”
Alon Harris, PhD, Indiana University

Symposium 8: Brain microcirculation
Chair: Fabrice Dabertrand, PhD, University of Colorado

Speakers:

“Blood flow modelling in realistic microvascular networks focusing on layer specificity in topology and perfusion”
Franca Schmid, PhD, University of Zürich, Switzerland

“Modeling cerebral blood flow control: an integrated framework for linking macroscale changes in blood perfusion and oxygenation to cell level signaling”
Nikolaos Tsoukias, PhD, Florida International University

“Restoration of neurovascular coupling by exogenous phosphatidylinositol 4,5-bisphosphate (PIP2) application in small vessel disease of the brain”
Fabrice Dabertrand, PhD, University of Colorado

“Imaging cerebral microvascular structure, oxygen concentration and blood flow in animal models”
Sava Sakadzic, PhD, Harvard University, Cambridge, Mass.

NOTE TO JOURNALISTS: The APS Conference: Interface of Mathematical Models and Experimental Biology: Role of the Microvasculature will be held September 11–14 in Scottsdale, Ariz. To schedule an interview with the conference organizers or presenters, contact the APS Communications Office or call 301.634.7314. Find more research highlights in the APS News Room.

Physiology is the study of how molecules, cells, tissues and organs function in health and disease. Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 10,000 members and publishes 15 peer-reviewed journals with a worldwide readership.

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