Publications

As originally published in The Physiologist
Volume 46, Number 3, June 2003, pages 104-108

CiteTrack: Your Free Email-Alerting Service Finds Articles You Might Have Missed

APS Unveils an Open Access Choice for Authors of Physiological Genomics

Boron New Editor of News in Physiological Sciences

Cowley New Editor of Physiological Genomics

Montrose New Editor of AJP-Gastrointestinal and Liver Physiology

CiteTrack: Your Free Email-Alerting Service Finds Articles You Might Have Missed

    We continue to present the features of the new portal site from the Stanford’s HighWire Library of Sciences and Medicine, which allows you to search all of Medline as well as full-text articles from over 360 journals, including all of the APS journals. The portal site is at http://highwire.stanford.edu.
    When HighWire Press interviewed scientists about their needs for information retrieval and access, one of the major points was that researchers and their labs could scan only a few dozen journals among a lab team in terms of examining them for important articles. One lab reported on an informal time-limited study in which they found 30 articles related to the lab’s work in their “usual” journals, but when they looked broadly across many other journals, they found another 30 articles that were relevant and would have been overlooked. 
    HighWire’s new portal has a solution to this problem. It’s called CiteTrack, a free automated alerting service that can alert you on articles that match your interests by daily checking all new content in Medline and all of the new full-text articles in over 360 HighWire-based journals. You can focus on your core journals and let the CiteTrack service track hundreds or thousands of other journals for you. 
    If CiteTrack finds a match with a term or author you have specified, you will get an Email the same day the article is published. The Email gives you the full author/title/citation to the newly published article plus a hyperlink to get you right to it. 
    You can register as many CiteTrack alerts as you would like, each with a different set of keywords and/or authors. You can also be alerted when articles of interest to you are cited and see who cited them (perhaps citations to your own articles!). You can tell CiteTrack to look only in particular journals (perhaps the ones in your journal club), in journals that publish in particular topics, in all 360+ HighWire-based journals’ full-text articles, or across all of HighWire plus all of Medline (over 4,500 journals). The choice is yours.
    In the near future, you’ll be able to tell CiteTrack that you are interested in certain topics—defined by detailed subject categories—and have CiteTrack tell you whenever new content is published in your favorite categories. This will allow you to match your specific interests without having to figure out all the possible keywords and authors that determine those interests. You’ll be able to receive a daily or weekly list of articles published—the table of contents for a “virtual journal” that matches just your interests. 
How to set up CiteTrack alerts: 
    Just click on the My Email Alerts link on the HighWire home page at http://highwire.stanford.edu. From the My Email Alerts page you can create an alert by author, by words in the title or abstract, or by text anywhere in an article. 
    The My Email Alerts page also shows you all your Email tables of contents alerts (“eTOCs”) as well as allows you to sign up for having content delivered to your Palm/PDA. You can also decide to be notified when the Articles in PresS (articles published ahead of print) are published in your journal of choice.
    If you are not a registered user of the HighWire portal or haven’t signed in when you clicked on My Alerts, you’ll see a link to register or sign in. Registration takes only a minute or two; it’s fast and free. And once you’ve registered, other new features discussed in this series become available to you, such as “My Favorite Journals.” 

APS Unveils an Open Access Choice for Authors of Physiological Genomics

    Starting July 1, 2003, authors of APS’s newest journal, Physiological Genomics, can choose to pay a $1,500 fee to have their article published online with Open Access from the first date of publication or choose to pay no author fees and leave their article under Subscription Access. Open Access means that those online articles are completely free to any person or any library. All online content associated with that article (text, figures, supplemental material) is freely accessible. 
    Here’s how it works:
    Upon acceptance, the author will be asked to download a form, where he or she will choose author-fee-based Open Access or Subscription Access. If Open Access is chosen, the author will be asked to provide a credit card number, purchase order, or check for $1,500. Once the payment or purchase order is processed, that online article will be made free to all. The print and online journal containing the article will still be available for a subscription fee, but that article will be free online because the author has paid the fee. 

Boron New Editor of News in Physiological Sciences

  Walter Boron, Professor of Cellular and Molecular Physiology at the Yale University School of Medicine, will succeed Stanley Schultz as the Editor of News in Physiological Sciences on July 1, 2003. Boron was born in Elyria, OH, where he received his education through high school. He attended St. Louis University where he earned an AB in chemistry summa cum laude in 1971. Boron then entered the Medical Scientist Training Program at Washington University in St. Louis where he did his graduate work under the tutelage of Albert Roos in the Department of Physiology and Biophysics. Boron received his MD and PhD degrees in 1977. After remaining with Roos for one year as a postdoctoral fellow, Boron moved as a postdoctoral fellow to the Department of Physiology at Yale in 1978, and joined the laboratory of Emile Boulpaep. In 1980, Boron joined the faculty of that department. He was promoted to Associate Professor in 1984 and Professor in 1987. Between 1989 and 1998, he served three three-year terms as Chairman of the Department.
    As a graduate student, using microelectrodes to measure intracellular pH (pHi) in squid giant axons and giant-barnacle muscle fibers, Boron was one of the first to monitor transient changes in pHi. With Paul De Weer, Boron observed and elucidated the pHi changes caused by applying and withdrawing NH3/NH+4 or CO2/HCO–3. The result was the introduction of the NH+4 prepulse technique, which is still widely used to acid load cells, as well as the first dynamic evidence that cells actively regulate their pH. The work that Boron did with DeWeer and with John Russell was pivotal in the initial description of the Na+-driven Cl-HCO3 exchanger, the first acid-base transporter implicated in pHi regulation. As a postdoctoral fellow, Boron, together with Boulpaep, discovered the electrogenic Na/HCO3 cotransporter, which plays a central role in HCO–3 reabsorption in the renal proximal tubule.
    As an independent investigator at Yale, Boron continued to elucidate mechanisms of pHi regulation, and has more recently focused in three related areas: the molecular physiology of Na+-coupled HCO–3 transporters, CO2 permeability, and CO2 sensors. Regarding general principles of pHi regulation, Boron and his coworkers were among the pioneers in using pH-sensitive dyes for monitoring pHi. They also developed now-standard paradigms for measuring the pHi dependencies of intracellular buffering power and the rates of acid-base transporters. By applying these paradigms to serum-starved cells studied in the presence versus the absence of HCO–3, they disproved the theory that growth factors act by raising pHi. Another product of this line of research was the discovery that, for most cells, the Na-H exchanger is rather active at the resting pHi. Regarding the molecular physiology of HCO–3 transporters, his group cloned the cDNA for the first Na+-coupled HCO–3 transporter—the renal electrogenic Na/HCO3 cotransporter. They also cloned and characterized the electroneutral Na/HCO3 cotransporter and the Na+-driven Cl-HCO3 exchanger, and continue to elucidate mechanisms of action and structure-function relationships for all of the above transporters. Regarding CO2 permeability, the work of Boron’s group on isolated-perfused gastric glands and colonic crypts led to the discovery of gas-impermeable membranes. Most recently, Boron’s group has shown that water channels, such as AQP1, are permeable to CO2 gas. His group also developed a novel rapid-mixing technique for making out-of-equilibrium CO2/HCO–3 solutions with virtually any combination of [CO2], [HCO–3] and pH. This approach, applied to the renal proximal tubule, has recently led to the first physiological description of a CO2 sensor.
    Boron has been an active member of APS since 1981. In the Renal Section, he served as Program Representative (1984–1987) and later as Chair of the Renal Section (1990–1993). The Berliner Lectureship was established during his tenure as Chair. Boron served on the APS Council (1995–1998) and then as President-Elect/President/Past-President (1998–2001). The Strategic Planning Meeting at Kiawah Island was held during his Presidency. With the Society of General Physiologists, Boron served as Treasurer (1988–1991).
Boron’s editorial experience includes membership on the Editorial Boards of the American Journal of Physiology-Renal, Fluid and Electrolyte Physiology (1984–1988) and the Journal of Physiology (London) (1985–1992). With the Annual Review of Physiology, he was a Special Section Editor of volume 48 in 1986. With Physiological Reviews he was Associate Editor (1985–1990) and then Editor (1994–1999). Finally, together with Boulpaep, Boron edited a new, comprehensive textbook for medical and graduate students, Medical Physiology. A Cellular and Molecular Approach, which was published by Saunders in 2003.
    Boron was a Searle Scholar from 1981–1984. He won the Young Investigator Award of the American Society of Nephrology and the American Heart Association in 1986. For excellence in teaching at Yale, Boron received the Charles W. Bohmfalk Teaching Award in 1993. That same year, he received the Robert F. Pitts Lectureship Award from the Renal Commission of the International Union of Physiological Sciences. In 1998, he received the Carl W. Gottschalk Distinguished Lectureship Award from the Renal Section of the American Physiological Society. That same year, he was also elected a Fellow of the American Association for the Advancement of Science. Boron’s research is funded by the National Institutes of Health and the Office of Naval Research. In 2002, Boron received a MERIT award from the NIDDK. 

Cowley New Editor of Physiological Genomics

On July 1, 2003, Allen W. Cowley, Jr., Professor and Chairman of the Department of Physiology at the Medical College of Wisconsin, will be the new editor of Physiological Genomics. Cowley completed his PhD degree training in physiology in 1968 with John Scott at Hahnemann Medical School in Philadelphia, PA. He then joined Arthur Guyton at the University of Mississippi Medical Center for postdoctoral training in 1968 and continued in that department until 1980. He was visiting professor of physiology at Harvard Medical School in 1974 and 1975, working with Clifford Barger and Claude Lechene. In 1980, he was appointed the Chairman of the Department of Physiology at the Medical College of Wisconsin in Milwaukee, WI.
    The central theme of his research has been related to the study of renal and vascular mechanisms involved in the long-term control of arterial pressure. His research during the first decade of his career was focused on whole animal systems physiological studies of cardiovascular and renal function. During the past decade, his research has focused additionally on the applications of molecular genomics to the understanding of complex physiological processes. 
    His early work on the baroreceptor reflexes in dogs demonstrated that although the baroreceptors participated importantly in the short-term stabilization of arterial blood pressure, they did not determine the long-term set point around which arterial pressure oscillated. He pioneered the use of continuous, 24-hour recording techniques coupled with computer averaging to quantify long-term average levels of arterial blood pressure and demonstrated that sinoaortic baroreceptor denervation did not alter the average level of blood pressure. His work with the renin-angiotensin and the vasopressin systems represented the first studies to quantitate the open-loop feedback gain of these blood pressure control systems. 
    Much of Cowley’s work has focused on achieving an understanding of the relationship between body fluid volume and arterial pressure regulation and the integration of these two elements. Studies in his laboratory and his collaborations uncovered the importance of medullary blood flow and related changes in renal interstitial pressure mechanism of pressure-diuresis. He has pioneered studies in conscious rats exploring the role of the renal medulla and demonstrated that small reductions of blood flow to the renal medulla alone can result in sodium retention and hypertension. Studies in his laboratory have also demonstrated that chronic elevations of blood volume as small as five percent could result in locally induced increases (autoregulation) of total systemic vascular resistance supporting the hypothesis that initial reductions of renal excretory function with only small expansion of blood volume can lead to significant increases of systemic vascular resistance. 
    Since 1993, his work has been directed toward searching for regions on rat and human chromosomes that segregate with the physiological pathways that determine arterial blood pressure (quantitative trait loci) using human subjects and inbred lines of rats. The applications of molecular genetics to the understanding of physiological function represents the central theme of most of his current research. This work has recently culminated in the first comprehensive systems biology genetic map of cardiovascular function published in Science in 2001. With the sequencing of the rat genome now complete, Cowley is now using techniques of chromosomal substitution in rats (consomic and congenic) together with large DNA expression arrays to determine the relationship of specific genetic pathways to complex physiological and pathophysiological pathways. 
    Cowley has authored more than 235 publications and has contributed chapters to 32 books. He has been an active member of the APS since 1972, serving as Councillor for the Society for five years, Chairman of the Water and Electrolyte Homeostasis Section and most recently, President of the Society in 1998. He has also served on the executive councils of several other scientific societies, including the American Heart Association (AHA) Council for High Blood Pressure Research, the AHA Basic Science Council, and the Inter-American Society of Hypertension. He has served as Chairman for the Council for High Blood Pressure Research of AHA and as President of the Association of Chairmen of Departments of Physiology. He currently serves as the President of the International Union of Physiological Sciences. He has served on numerous NIH study sections including the NHLBI Advisory Council and has served on more than 10 editorial boards, including three journals of APS.
    Cowley is director of the NIH Specialized Center for Hypertension Research at the Medical College of Wisconsin, which has as its emphasis the search for genes responsible for high blood pressure. He directs the NIH Program “Blood Pressure-Determinants and Controllers” now in its 26th year of continuous funding. He co-directs an NIH Program of Genomic Applications (PGA) for the development of genetic model organisms that will link genes to function. He is the director of a NIH training grant in high blood pressure research and, throughout his career, has trained more than 30 postdoctoral fellows and students. He received the Distinguished Achievement Award of the Scientific Councils of the AHA in 1996 and the Novartis Award from the Council for High Blood Pressure Research of the AHA in 1997. He was the 1996 Ernest H. Starling Distinguished Lecturer of the APS Water and Electrolyte Homeostasis Section and the 2002 recipient of the Walter B. Cannon Award of the APS. 

Montrose New Editor of AJP-Gastrointestinal and Liver Physiology

   Marshall (Chip) Montrose, Professor of Cellular and Integrative Physiology at Indiana University, will succeed Martin Kagnoff as Editor-in-Chief of the American Journal of Physiology-Gastrointestinal and Liver Physiology in July 2003. Born in Bethesda, MD (under the shadow of the NIH from an early age), he received his BS in Mathematics and Zoology from the University of Maryland in 1977. After working as a technician at the NIH for two years, he decided to pursue a PhD in Biophysics under the watchful eye of George Kimmich at the University of Rochester, NY. Graduating in 1984, he went to Switzerland for joyful postdoctoral work with Heini Murer. In 1988, Mark Donowitz bravely recruited him to join the GI Division in the Department of Medicine at Johns Hopkins University as Assistant Professor, despite the fact that his postdoctoral work was in renal epithelial cells. After ten years at Johns Hopkins, he took his current position at Indiana University.
    His research has been dominated by developing an understanding about the membrane physiology of gastrointestinal epithelial cells, with a passion for understanding acid/base transport regulation. He recently realized that he has published research work on every segment of the GI tract from the mouth to colon. His recent application of advanced microscopy methods to living native tissue in vivo and in vitro have allowed unprecedented opportunities for exploring parts of cells and tissues that have historically defied deep analysis.    Most notably, explorations of pH microdomains surrounding epithelial cells have both raised and answered questions about the regulation of acid/base transporters in the intimate spaces near membranes. 
    He has been an Associate Editor for AJP-GI and editorial board member for AJP-Cell Physiology for a number of years. He currently serves as a Councilor for the Intestinal Disorders section of the American Gastroenterological Association and also recently served as councillor for the Cell and Molecular Physiology Section of APS. 

[June 2003 Index] [ACDP Survey 2002] [Membership] [Education] [APS Web News] [Public Affairs] [News From Senior Physiologists] [Positions Available] [Book Reviews] [Guyton Obituary] [People & Places] [Announcements] [Scientific Meetings and Congresses] [APS Membership Application]