© The American Physiological Society - Publications - Physiological Genomics

The images here represent recent content posted to the Physiological Genomics site. Some are images directly from published articles, and others are supplementary to the content of published articles.

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	Mouse embryo visualized by transcutaneous ultrasound imaging at 40 MHz at day 13.5 of gestation; embryonic eyes and brain are visible. For further discussion, see article by Zhou YQ, Foster FS, Qu DW, Zhang M, Harasiewicz KA, and Adamson SL. Applications for multifrequency ultrasound biomicroscopy in mice from implantation to adulthood. Physiol Genomics 10: 113-126, 2002. First published June 18, 2002; 10.1152/physiolgenomics.00119.2001.

	Triple labeling of rat extraocular muscle showing basal lamina (green), sarcolemma (red), and muscle nuclei (yellow). Expression profiling suggests that the increased expression of growth factors and/or number of satellite cells (seen in the middle of the micrograph), may underlie the greater predicted regenerative potential compared with limb muscles. For further discussion, see article by Fischer MD, Gorospe JR, Felder E, Bogdanovich S, Pedrosa-Domellöf F, Ahima RS, Rubinstein NA, Hoffman EP, and Khurana TS. Expression profiling reveals metabolic and structural components of extraocular muscles. Physiol Genomics 9: 71-84, 2002. First published March 5, 2002; 10.1152/physiolgenomics.00115.2001.

	Pattern of expression for the tyrosine hydroxylase gene in the brain, reconstructed using gene expression tomography (GET). In the image, the gene (represented here in pseudo-color) can be seen to be expressed in the locus coeruleus. Brain image is from the Mouse Brain Library and Atlas (http://www.mbl.org). GET should be a useful new methodology for high throughput acquisition of brain gene expression patterns. For further discussion, see the article (release 8.2): Brown VM, Ossadtchi A, Khan AH, Gambhir SS, Cherry SR, Leahy RM, and Smith DJ. Gene expression tomography. Physiol Genomics 8: 159-167, 2002. First published January 29, 2002; 10.1152/physiolgenomics.00090.2001.

	Mice lacking a lens-specific water channel (aquaporin-0) develop cataracts. See related article by Shiels A, Bassnett S, Varadaraj K, Mathias R, Al-Ghoul K, Kuszak J, Donoviel D, Lilleberg S, Friedrich G, and Zambrowicz B. Physiol Genomics 7: 179-186, 2001. First published online November 6, 2001; 10.1152/physiolgenomics.00078.2001.

	Active (L) and dormant (R) thirteen-lined ground squirrel, Spermophilus tridecemlineatus. This hibernating mammal utilizes efficient physiological mechanisms to minimize energy consumption during the winter. The process involves not only a decrease in the overall metabolic rate, but also a metabolic shift from preferential use of carbohydrates to triacylglycerols. One such metabolic shift enables it to utilize free fatty acids as a primary energy source during the coldest months of hibernation. For further discussion, see the article by Buck MJ, Squire TL, Andrews MT. Coordinate expression of the PDK4 gene: a means of regulating fuel selection in a hibernating mammal. Physiol Genomics 8: 5-13, 2002. First published November 27, 2001; 10.1152/physiolgenomics.00076.2001. Also, see the accompanying Editorial Focus article. Glueck SB and Heldmaier G. Settling down for a long winter's nap: focus on "Coordinate expression of the PDK4 gene: a means of regulating fuel selection in a hibernating mammal." Physiol Genomics 8: 3-4, 2002; 10.1152/physiogenomics.00118.2001.

	Left ventricular cardiomyocytes from 14-week-old hypertrophic heart rats (HHR, top) and normal rats (NHR, bottom). The hypertrophic heart rat model is characterized by enlarged cardiomyocytes and left ventricular hypertrophy. For further discussion see the article by Harrap SB, Danes VR, Ellis JA, Griffiths CD, Jones EF, Delbridge LM. The hypertrophic heart rat: a new normotensive model of genetic cardiac and cardiomyocyte hypertrophy. Physiol Genomics 9: 43-48, 2002. First published February 25, 2002; 10.1152/physiolgenomics.00006.2002.

	Shown is a pupal stage retina from a Drosophila transgenic animal expressing P35, the baculovirus inhibitor of apoptosis protein, from a retina-specific promoter (transgene construct is called GMR-p35). Excess cells are present due to a block in cell death. All cells are outlined by fluorescent immunostaining using Drosophila anti-Armadillo as the primary antibody. For further discussion see the review article by Gorski SM, and Marra M. Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol Genomics 9: 59-69, 2002; 10.1152/physiolgenomics.00114.2001.

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