-
Robert A. Brodsky, MD. Narrative Review:
Paroxysmal Nocturnal Hemoglobinuria: The Physiology of
Complement-Related Hemolytic Anemia. Ann Intern Med 148: 587-595,
2008 (posted 4/15/08).
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John H. Newman, MD; John A. Phillips III, MD; and James E.
Loyd, MD. Narrative Review: The Enigma of Pulmonary
Arterial Hypertension:
New Insights from Genetic Studies. Ann Intern Med 148: 278-283,
2008 (posted 2/20/08).
-
Joe T.R. Clarke, MD, PhD. Narrative
Review: Fabry Disease. Ann Intern Med 146: 425-433, 2007 (posted
3/20/07).
-
Eyal Reinstein, MD, PhD, and Aaron Ciechanover, MD, DSc.
Narrative Review: Protein Degradation and Human
Diseases: The Ubiquitin Connection. Ann Intern Med 145: 676-684,
2006 (posted 11/7/06).
-
Amy Theos, MD, and Bruce R. Korf, MD, PhD.
Pathophysiology of Neurofibromatosis Type 1. Ann
Intern Med 144: 842-849, 2006. (posted 6/6/06)
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Jonathan M. McGavock, PhD; Ronald G. Victor, MD; Roger H.
Unger, MD; and Lidia S. Szczepaniak, PhD.
Adiposity of the Heart, Revisited. Ann Intern Med
144: 517-524, 2006 (posted 4/4/06).
-
Jeff M. Sands, MD, and Daniel G. Bichet, MD.
Nephrogenic Diabetes Insipidus. Ann Intern Med
144:186-194, 2006. (posted 2/13/06)
-
Giorgos Bamias, MD; Mark R. Nyce, MD; Sarah A. De La Rue,
PhD; and Fabio Cominelli, MD, PhD. New Concepts in
the Pathophysiology of Inflammatory Bowel Disease. Ann Intern Med
143: 895-904, 2005. (published 12/20/05; posted 1/6/06)
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Timothy D. Starner, MD, and Paul B. McCray Jr., MD.
Pathogenesis of Early Lung Disease in Cystic Fibrosis:
A Window of Opportunity To Eradicate Bacteria. Ann Intern Med
143: 816-822, 2005. (published 12/6/05; posted 1/6/06)
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Hyon K. Choi, MD, DrPH; David B. Mount, MD; and Anthony
M. Reginato, MD, PhD. Pathogenesis of Gout.
Ann Intern Med 143: 499-516, 2005. (published 10/4/05; posted 1/6/06)
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Sean M. Caples, DO; Apoor S. Gami, MD; and Virend K. Somers,
MD, PhD. Obstructive Sleep Apnea. Ann Intern
Med 142: 187-197, 2005. (posted 2/1/05)
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John B. West, MD, PhD. The
Physiologic Basis of High-Altitude Diseases. Ann Intern Med
141:789-800, 2004. (posted 11/16/04)
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Claude A. Piantadosi, MD, and David A. Schwartz, MD, MPH. The
Acute Respiratory Distress Syndrome. Ann Intern Med 141: 460-470,
2004. (posted 9/22/04)
-
Dennis J. Selkoe, MD. Alzheimer
Disease: Mechanistic Understanding Predicts Novel Therapies. Ann
Intern Med 140: 627-638, 2004. (posted 4/22/04)
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Clifford J. Woolf, MD. Pain: Moving from Symptom
Control toward Mechanism-Specific Pharmacologic Management. Ann
Intern Med 140: 441-451, 2004. (posted 3/22/04)
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Sergio A. Jimenez, MD, and Chris T. Derk, MD. Following
the Molecular Pathways toward an Understanding of the Pathogenesis of
Systemic Sclerosis. Ann Intern Med 140: 37-50, 2004. (posted
1/7/04)
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Suzanne Oparil, MD; M. Amin Zaman, MD; and David A. Calhoun, MD. Pathogenesis
of Hypertension. Ann Intern Med 139: 761-776, 2003. (posted 11/4/03)
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Peter J. Barnes, DM, DSc, and Ian M. Adcock, PhD. How
Do Corticosteroids Work in Asthma? Ann Intern Med 139: 359-370, 2003.
(posted 9/3/03)
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J. Enrique Silva, MD. The
Thermogenic Effect of Thyroid Hormone and Its Clinical Implications. Ann
Intern Med 139: 205-213, 2003. (posted 8/21/03)
-
Hershel Raff, PhD, and James W.
Findling, MD. A Physiologic Approach to Diagnosis of the Cushing
Syndrome. Ann Intern Med 138: 980-991, 2003. (posted 6/17/03)
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Daniel J. Brat, MD, PhD,
and Timothy B. Mapstone, MD. Malignant Glioma Physiology: Cellular
Response to Hypoxia and Its Role in Tumor Progression. Ann Intern Med 138: 659-669, 2003.
(posted 5/8/03)
Physiology in Medicine (PIM) is a bimonthly series of articles
published jointly by APS and Annals of Internal Medicine. It is printed
in Annals and is provided free online to APS through the links below. The aim
of this series is to provide practicing MD’s and/or researchers an up-to-date
physiological understanding of disease with the proper application of new
molecular models and tools. Articles published in this series are intended to
provide a thoughtful and lucid linkage of science to the patient.