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David Linden, Ph.D.
David Linden is Professor of Neuroscience at The Johns Hopkins
University School of Medicine in Baltimore, Maryland. Following
undergraduate work at the University of California, Berkeley with Joe
Martinez, he performed his doctoral research in the lab of Aryeh
Routtenberg at Northwestern University, examining the role of protein
kinase C in long term synaptic potentiation and modulation of
voltage-gated ion channels. In 1990, he began postdoctoral work with
John Connor at the Roche Institute of Molecular Biology, where, together
with several colleagues, he developed a cell culture system to study
cerebellar long-term synaptic depression, a putative memory mechanism.
He joined the faculty of the Department of Neuroscience at Johns Hopkins
University School of Medicine in 1992, where he remains, propped up at
his rig by an impressive stack of unread documents.
Linden’s laboratory has used single cell recording and imaging techniques
in brain slices and cultures to examine the cellular and molecular basis of
information storage, often using the cerebellum as a model system. Other
interests of the lab include synaptic transmission, neuron-glia
communication, ion channel modulation, and, more recently, dynamic imaging
of neuronal, glial and vascular fine structure in the intact brain. A list
of some of the lab’s recent papers may be found
here.
Linden has a long standing interest in scientific communication, serving
on the Editorial Boards of Journal of Neurophysiology, Neuron,
and The Cerebellum. He is author of a neuroscience book for a
general audience, The Accidental Mind: How Brain Evolution Has Given Us
Love, Memory, Dreams and God (Belknap/Harvard, 2007). He intermittently
blogs at accidentalmind.org.
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