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The American Physiological Society is proud to announce that the
full historical content of its 14 journals, going back to the very
first issues of the American Journal of Physiology in 1898,
is now available online. To commemorate this event, we have asked
authors to write essays on some of the most significant articles
from the body of APS literature.
Introduction to the classic papers
commemorating the APS Legacy Project
by Hershel Raff, Dale Benos, and Margaret Reich
View the
Original Classic Articles
Want to suggest a classic
article in Physiology? Want to write an essay on one?
Contact Dale Benos or
one of the Editors in Chief.
Submission Guidelines
Read the First Issue of Each Journal FREE!
Honoring Our
Past
Introduction to the JN Classic Articles by
Eve Marder
Click on an author or title below to read the commemorative
essays:
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Adrenal cortex: scalpels, syringes, and separatory funnels
by Susan F. Akana |
The physiology of the peripheral vestibular system: the birth of a
field
by Dora E. Angelaki |
Comments on Classical Papers
by K. M. Baldwin |
The exercise dose response: key lessons from the past
by Marcas M. Bamman |
Postnatal Developmental Renal Physiology: A Study of Historic
Significance
by Michel Baum |
Alpha and Beta Adrenergic Receptors: Ahlquist's
Landmark Hypothesis of a Single Mediator with Two Receptors
by David B. Bylund |
Estimation of dose-response curves and identification
of peaks in hormone pulsations: classic marriages of statistics to
science
by Douglas Curran-Everett |
Adrenocortical function, feedback, and alphabet soup
by Mary F. Dallman |
The use of mammalian cortical kidney slices for the study of tubule
secretion: a pioneering step toward understanding organic anion
transport
by William H. Dantzler |
Berne’s adenosine hypothesis of coronary blood flow control
by Eric O. Feigl |
Acute hypoxia and pulmonary vasoconstriction in humans: uncovering
the mechanism of the pressor response
by Alfred P. Fishman |
Two classic papers in acid-base physiology: contributions of
R. F. Pitts, R. S. Alexander, and W. D. Lotspeich
by Gerhard Giebisch
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Discovery of the luteinizing hormone of the anterior
pituitary gland
by H. Maurice Goodman
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Studying the visual system in awake monkeys: two
classic papers by Robert H. Wurtz
by Michael E. Goldberg |
Roger Sperry: pioneer of neuronal specificity
by Bernice Grafstein
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Relating cardiac performance with oxygen consumption:
historical observations continue to spawn scientific discovery
by David D. Gutterman and
Allen W. Cowley, Jr.
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The pioneering use of systems analysis to study
cardiac output regulation
by John E. Hall
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Ca-induced Ca release: lessons regarding cell models
by David R. Harder
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Synaptic chemistry in single neurons: GABA is identified as an
inhibitory neurotransmitter
by Ronald Harris-Warrick |
The development of clearance methods for measurement of glomerular
filtration and tubular reabsorption
by T. H. Hostetter and T.W. Meyer
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Nature vs. nurture: can exercise really alter fiber type composition
in human skeletal muscle?
by Christopher P. Ingalls
|
 A
dogged pursuit of coincidence
by Philip X. Joris |
 Muscle,
liver, and pancreas: Three Musketeers fighting to control glycemia
by Amira Klip and Mladen Vranic |
Dead space: Simplicity to complexity
by Robert A. Klocke |
 Significance
of urea transport: the pioneering studies of Bodil Schmidt-Nielsen
by Juha P. Kokko and Jeff M. Sands |
 Hypothalamic control of body temperature: insights from the past
by Gary W. Mack
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Placing pain on the sensory map: Classic papers by Ed Perl and
colleagues
by Peggy Mason |
Making the retina approachable
by Gary Matthews |
The
size principle: a rule describing the recruitment of motoneurons
by Lorne M. Mendell
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Microvascular permeability, ultra-filtration, and
restricted diffusion
by C. C. Michel |
Sex-based physiology prior to political correctness
by Virginia M. Miller |
Stresses on pulmonary blood vessels
by Wayne Mitzner |
The basis for transport across epithelial cells
by Marshall H. Montrose |
Comroe's study of aortic chemoreceptors: a path well chosen
by Judith A. Neubauer
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The significance of the blood gas analyzer
by Hershel Raff
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Discovering the role of the adrenal gland in the control of body function
by David C. Randall
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Eugene M. Landis and the physiology of the microcirculation
by E. M. Renkin
|
 Discovering
the mechanism of capacitative calcium entry
by Juan A. Rosado
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Micropuncture: unlocking the secrets of renal function
by Jeff M. Sands
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Experimental validation of the countercurrent model of urinary
concentration
by James A. Schafer
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What do dendrites and their synapses tell the neuron?
by Idan Segev |
First electrodes for blood Po2 and Pco2 determination
by John W. Severinghaus |
Anterior pituitary hormones: development of a bioassay leading to the
discovery of prolactin
by M. Susan Smith |
Aristides Leão’s discovery of cortical spreading depression
by G. G. Somjen |
 Renal
Potassium Transport: The pioneering studies of Gerhard Giebisch
by Bruce A. Stanton |
Dr. Bernice Grafstein’s paper on the mechanism of spreading
depression
by Anthony J. Strong |
The paper that completely altered our thinking about cerebral blood
flow measurement
by Richard J. Traystman |
 The
beginning of a fantastic, unanswered question: is 5-HT involved in
systemic hypertension?
by Stephanie W. Watts |
Understanding pulmonary gas exchange: ventilation-perfusion
relationships
by John B. West |
 Circuits
and Properties of Signal Transmission in the Retina
by Paul Witkovsky, William K. Stell, and Andrew T. Ishida |
Discovering spatial working memory fields in prefrontal cortex
by Xiao-Jing Wang |
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