The Role of the Extracellular Matrix in Gastrointestinal and Liver Physiology

The extracellular matrix (ECM), once thought to be an inert scaffold to which cells anchor, is increasingly recognized as a major, dynamic entity that profoundly impacts tissue homeostasis and function through multiple complex mechanisms that we are only beginning to understand. Some of these proposed functions include “outside in” cell signaling to cells through integrins and other cell surface receptors, serving as a depot to cytokines and growth factors, and release of biologically active matrix fragments upon ECM degradation and remodeling. In disease, fibrotic changes in the ECM composition, cross-linking and stabilization of the major extracellular proteins (collagens, elastin, and others) trigger potent pathological signals that directly contribute to disease progression. Studies that elucidate the ECM biology in health and disease are instrumental to devising innovative therapies for liver and gastrointestinal diseases and will be of great interest to readers of the American Journal of Physiology-Gastrointestinal and Liver Physiology.

All manuscripts should be submitted online via eJournalPress. During the online submission process, under the “Keywords & Special Sections” tab, please use the “Category” drop-down menu and select “Call for Papers: The Role of the Extracellular Matrix in Gastrointestinal and Liver Physiology”.

Manuscripts will undergo normal peer review as they are received. Accepted manuscripts will be published online as they are accepted. Articles published from this Call for Papers will be highlighted at the time of publication. The collection may also include specially commissioned research articles related to the topic.

Manuscripts can be submitted anytime, but to be eligible for inclusion in this Call for Papers, manuscripts must be submitted by October 1, 2018.