Senescence in the Lung

The American Journal of Physiology-Lung Cellular and Molecular Physiology is issuing a call for papers addressing cell senescence in lung physiology and disease.

Cellular senescence results in cell cycle arrest accompanied by the secretion of cytokines, chemokines, growth factors, and remodeling proteins (a “senescence-associated secretory phenotype”; SASP) that have autocrine and paracrine effects in the tissue microenvironment. SASP can promote remodeling, inflammation, infectious susceptibility, angiogenesis, and proliferation, while at the same time hindering tissue repair and regeneration. While senescence and senescent cells are increasingly recognized as mediators of disease states, relatively less is known about the portfolio and influence of senescent cells in normal lung growth and homeostasis, and aging per se, or in the induction or progression of lung diseases across the age spectrum such as bronchopulmonary dysplasia, asthma, COPD, or pulmonary fibrosis. There is tremendous scope to improve our understanding of the mechanisms and role of cell senescence and the role played by cell senescence in the lung. The current state of our knowledge about senescence in the healthy and disease lung has been summarized in a recent review in our Journal by our Associate Editor Y.S. Prakash and coworkers (doi:10.1152/ajplung.00424.2018), accompanied by a related Editorial that served to launch this Call for Papers (doi:10.1152/ajplung.00081.2019).

Original manuscripts addressing any aspect of senescence in the lung, including the physiology and homeostasis of the healthy lung, as well as the role of senescence in lung disease, can be submitted in response to this Call for Papers. Manuscripts addressing any of the following specific topics related to cell senescence in the lung are particularly encouraged:

  1. Manuscripts that address the induction of senescence in childhood, and the role of environmental, allergic, or infectious exposures during childhood that might impact the induction of senescence throughout the course of life.
  2. Manuscripts that identify and explore the influence of gender or sex on the role played by senescence in lung (patho)physiology.
  3. Manuscripts that address the induction and role of senescence in asthma.
  4. Manuscripts that identify and examine the cell-surface stability of surface markers that can differentiate senescent cells.
  5. Manuscripts that examine the interaction between senescence pathways and defined pathogenic pathways in lung disease.
  6. Manuscripts that clarify the contribution of senescence to developmental processes, such as spatiotemporal patterning in the developing lung.
  7. Manuscripts that examine the mechanisms of clearance of senescent cells in the heathy, developing, and diseased lungs.
  8. Manuscripts that address the differential susceptibility of lung cell-types to senescence, and the potential contribution of differential cell-type susceptibility to disease.
  9. Manuscript that address the specific features of senescent cells that contribute to the “good” versus the “bad” in contributing to lung diseases of ageing.
  10. Manuscripts that address how to impart cell selectivity to senolytic therapies.

Additionally, reviews on aspects of senescence in the lung will also be considered, but a pre-submission inquiry should be made to the email address below. All manuscripts should be submitted online via eJournalPress. During the online submission process, under the “Keywords & Special Sections” tab, please use the “Category” drop-down menu and select “Call for Papers: Senescence in the Lung”.

All manuscripts will be reviewed promptly, thoroughly, and fairly by members of the Editorial Board and guest reviewers who are recognized experts in this field. Accepted manuscripts will be published online within two weeks after acceptance under a distinct heading and will receive special attention and handling. In addition, the Editor will solicit an annual Perspective on this area to review seminal findings.

Authors should indicate in their letter to the editor and in the online submission form under “Manuscript Type” that the submitted manuscript is in response to a special Call for Papers. If you currently have a manuscript on this topic that has already been submitted and would like it to be included in this special Call, please contact Dr. Rory E. Morty, Editor-in-Chief ,via e-mail at

Deadline for submissions: December 31, 2019.