Role of gut microbiota, gut-brain, and gut liver axes in physiological regulation of inflammation, energy balance, and metabolism

Over the past 10 years, gut microbiota composition and activity have been increasingly associated with host energy, glucose and lipid metabolism. Evidence suggests that gut microbes communicate with host mammalian cells, however, the key mechanisms remain poorly understood. External factors such as nutrients, dietary habits, but also pollutants or food additives may influence this multifaceted ecosystem. Microbial metabolites and components have been shown to interact with specific host receptors involved in the control of energy metabolism by a gut-to-brain axis (e.g., gut peptides, neurotransmitters) but also in the gut-to-liver axis (e.g., metabolic endotoxemia, short-chain fatty acids), thereby leading to dynamic interactions between microbes, dietary elements and organs.

The editors of AJP - E&M encourage submissions of novel data highlighting novel mechanisms of actions related to gut brain and gut liver axes, and eventually suggesting how such findings may become a novel therapeutic target. We will consider both original research articles and review articles. For review articles only, authors should email the editorial office (karen.dodson@wustl.edu) with a pre-submission inquiry including a working title, author and affiliation list, abstract, and brief outline of the content for approval by the editors.

Submission Deadline: September 30, 2017

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