Role of Gut Microbiota, Gut-Brain and Gut Liver Axes in Physiological Regulation of Inflammation, Energy Balance, and Metabolism

Over the last 10 years, gut microbiota composition and activity has been increasingly associated with host energy, glucose and lipid metabolism. Evidence suggests that gut microbes communicate with host mammalian cells, however the key mechanisms remain poorly understood. External factors such as nutrients, dietary habits but also pollutants or food additives may influence this multifaceted ecosystem. Microbial metabolites and components have been shown to interact with specific host receptors involved in the control of energy metabolism by a gut to brain axis (e.g., gut peptides, neurotransmitters) but also in the gut to liver axis (e.g., metabolic endotoxemia, short chain fatty acids) thereby leading to dynamic interactions between microbes, dietary elements and organs.

The editors of AJP-Endocrinology and Metabolism encourage submissions of novel data highlighting novel mechanisms of actions related to gut brain and gut liver axes, and eventually suggesting how such findings may become a novel therapeutic target. We will consider both original research articles and review articles. For review articles only, authors should email the editorial office ( with a pre-submission inquiry including a working title, author and affiliation list, abstract and brief outline of the content for approval by the editors.

Deadline for Submission: April 30, 2019