Many Avenues to Cardiac Cell Death

Guest Editors Dr. Lorrie Kirshenbaum, Dr. Takashi Matsui, and Associate Editor Dr. Junichi Sadoshima, along with the editorial team at AJP-Heart and Circulatory Physiology, invite submission of original research articles and review articles on the topic of “Many Avenues to Cardiac Cell Death.”

The loss of cardiac myocytes in diseases, such as myocardial infarction, ischemia-reperfusion injury and cardiomyopathy, has been suggested to underlie adverse cardiac remodeling that ultimately leads to a decline in cardiac performance and heart failure. While cardiomyocyte proliferation and regeneration have been reported under limited physiological conditions, therapeutic approaches that restore cardiac function after excessive loss of cardiomyocytes in pathological settings has not been well established. At the cellular level, the mitochondrion is a platform for regulating apoptosis and programmed necrosis. These processes are highly integrated at the molecular level and overlap with respect to disease. Recently, new forms of cell death, including autosis caused by excessive autophagy and ferroptosis (iron-dependent cell death characterized by defined morphological and biochemical features), have been reported. Thus, preventing cardiomyocyte death due to aberrant cardiac injury is still a viable approach for preserving cardiac function and preventing heart failure.

The editors welcome submissions that improve our understanding of the cell signaling pathways in cardiomyocyte cell death, cell survival factors, autophagy, and pathophysiological processes that lead to cardiac myocyte cell death. As well, the editors encourage submissions focusing on therapeutic targets against mitochondrial injury under pathophysiological stimuli including hemodynamic overload, ischemia-reperfusion injury, myocardial infarction, diabetic cardiomyopathy, and drug-induced cardiomyopathy. In particular, the editors are interested in submissions investigating novel approaches to preserve cardiac physiology in response to cardiac myocyte injury, such as those occurring with acute myocardial infarction, cardiac hypertrophy or heart failure.

We encourage submission of investigations employing a variety of experimental approaches and techniques, from studies in vitro to those performed in humans. Authors are encouraged to discuss the translational perspective of their basic research in animal models, in vitro, and computational studies with emphasis on future clinical perspectives.

We will consider both original research articles and relevant review articles. For review articles only, authors should email the editorial office ( a pre-submission inquiry including a working title, author and affiliation list, abstract and brief outline of the content for approval by the editors.

All manuscripts accepted from this Call for Papers will be included in a unique online article collection to further highlight the importance of this topic. The article collection will also include specially commissioned Review articles on the topic.

All manuscripts should be submitted online at

During the online submission process, under the “Keywords & Special Sections” tab, please use the “Category” drop-down menu and select “Call for Papers: Many Avenues to Cardiac Cell Death.”

Manuscripts will undergo normal peer review as they are received. Accepted manuscripts will be published online as they are accepted. Articles published from this Call for Papers will be highlighted with a special “Call for Papers” banner on the article PDF, as well as included in the “Call for Papers: Many Avenues to Cardiac Cell Death” online article collection at time of publication.

Manuscripts must be submitted by January 31, 2019 to be eligible for inclusion in this Call for Papers. If you have any questions please contact Kara Hansell Keehan, Executive Editor, via email at