Immune Regulation, Homeostasis, and Cancer in the Digestive System

As complex physiological systems, cancers develop mechanisms preventing the normal immune system from attacking and attenuating the promotion of gastrointestinal and other cancers. The field of cancer immunology is rapidly advancing with increased knowledge of immune alterations in cancers along with cancer immunotherapies designed to retard the progression of cancer. The mechanisms involved in both promotion of the cancer immune alterations as well as how the emerging therapies act are only partially understood and still require significant advances. Progress can occur not only in discovery of pathways involved and cancer immunoregulation but also in novel methods to study the complex interactions between cancer epithelia and participants in the cancer microenvironment, including immune and inflammatory cells. Advances can occur in novel animal model approaches as well as in microscopic and other methods of analysis that can be used to describe the unique contributions of immune/inflammatory cells in cancer development. Considerations of the mechanisms of gastrointestinal cancer using physiological principles are of great interest for readers of the American Journal of Physiology-Gastrointestinal and Liver Physiology.

All manuscripts should be submitted online via eJournalPress. During the online submission process, under the “Keywords & Special Sections” tab, please use the “Category” drop-down menu and select “Call for Papers: Immune Regulation, Homeostasis, and Cancer in the Digestive System”.

Manuscripts will undergo normal peer review as they are received. Accepted manuscripts will be published online as they are accepted. Articles published from this Call for Papers will be highlighted at the time of publication. The collection may also include specially commissioned review or research articles related to the topic.

Manuscripts can be submitted anytime, but to be eligible for inclusion in this Call for Papers, manuscripts must be submitted by October 1, 2018.