Extracellular Vesicles in Lung Health, Disease, and Therapy

The American Journal of Physiology-Lung Cellular and Molecular Physiology is issuing a call for papers on extracellular vesicles in lung health, disease, and therapy.

Both physiological homeostasis as well as pathological disease processes that occur the lung result from complex—yet, carefully coordinated—physiological pathways, which are synchronized via paracrine and endocrine intercellular communication. Extracellular vesicles are emerging as important information shuttles that can coordinate and disseminate homeostatic and disease signals. These extracellular vesicles, which are present in biological fluids such as sputum, mucus, epithelial lining fluid, edema fluid, blood, pleural fluid, and lymph, have emerged as promising candidate biomarkers with diagnostic and prognostic value in lung disease. Extracellular vesicles are small subcellular membranous vesicles containing cargo from parent cells, where cargo may take the form of lipids, proteins, genetic information, or entire organelles. The cargo thus endows extracellular vesicles with biologically active information (or function) by which the extracellular vesicles can reprogram target cells. Several recent studies have documented that extracellular vesicles found in lung-associated biological fluids play key roles as biomarkers and effectors of disease. Conversely, administration of naïve or engineered extracellular vesicles with homeostatic or reparative effects may provide us with a promising novel protective and regenerative strategy to treat lung disease. The current state of our knowledge about extracellular vesicles in lung health, disease, and therapy has been summarized in a recent review in our Journal by our Associate Editors Nathan W. Bartlett and Wolfgang Kuebler, and their coworkers (doi:10.1152/ajplung.00546.2018), which also served to launch this Call for Papers.

Original manuscripts addressing any aspect of extracellular vesicles in lung health, disease, and therapy can be submitted in response to this Call for Papers. Additionally, reviews on novel aspects of extracellular vesicle function in lung health, disease, and therapy—which have not been previously reviewed in the scientific literature—will also be considered, but a presubmission inquiry should first be made to the email address below. All manuscripts should be submitted online via eJournalPress During the online submission process, under the “Keywords & Special Sections” tab, please use the “Category” drop-down menu and select “Call for Papers: Extracellular Vesicles in Lung Health, Disease, and Therapy”.

All manuscripts will be reviewed promptly, thoroughly, and fairly by members of the Editorial Board and guest reviewers who are recognized experts in this field. Accepted manuscripts will be published online within two weeks after acceptance under a distinct heading and will receive special attention and handling. In addition, the Editor will solicit an annual Perspective on this area to review seminal findings.

Authors should indicate in their letter to the editor and in the online submission form under “Manuscript Type” that the submitted manuscript is in response to a special Call for Papers. Only those papers not requiring extensive revision will be published under this call. If you currently have a manuscript on this topic that has already been submitted and would like it to be included in this special Call, please contact Dr. Rory E. Morty, Editor-in-Chief, via e-mail at abrown@the-aps.org.

Deadline for submissions: December 31, 2019.