Endocannabinoids and cannabinoid receptors as regulators of endocrine functions and tissue metabolism

There is now growing appreciation that the endocannabinoid system (ECS) influences multiple physiological systems including the respiratory, cardiovascular, gastrointestinal, and endocrine systems via both central and peripheral actions. Major components of this system include the endogenous lipid-derived endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), which principally target cannabinoid (CB1 and CB2) G protein-coupled receptors but may also potentially interact with orphan receptors such as GPR55. Recent studies have highlighted that aberrant expression or overactivation of the CB1 receptor in peripheral tissues, for example, can affect pancreatic insulin secretion and modify cellular inflammatory responses as well as induce dysregulation of energy metabolism in key metabolic tissues, resulting in dyslipidemia, obesity, and insulin resistance. The editors of AJP -E&M recognize this as an important and emerging area of research whose increased understanding may be of considerable pharmacotherapeutic value in combatting conditions such as obesity and its related metabolic disorders.

The editors of AJP - E&M invite submission of original research articles that provide novel mechanistic insight at the cell, tissue, and/or whole body levels on how ECS modulation impacts upon endocrine functions, energy, and metabolic homeostasis. We particularly welcome submissions that explore how proximal ligand-induced CB1 and CB2 receptor signalling mechanistically links to pathways regulating tissue inflammation and mitochondrial energy metabolism as well as production and secretion of molecules with endocrine activity (e.g., insulin, myokines, adipokines). Studies reporting the effects of AEA and 2-AG on the above via novel noncanonical mechanisms are also welcome. We will consider both original research articles and review articles. For review articles only, authors should email the editorial office (karen.dodson@wustl.edu) with a pre-submission inquiry including a working title, author and affiliation list, abstract, and brief outline of the content for approval by the editors.

Submission Deadline: September 30, 2017