Chromatin and Epigenetics in Cardiovascular Disease

Guest Editors Timothy McKinsey and Thomas Vondriska, along with the editorial team of AJP-Heart and Circulatory Physiology, invite submission of original research and short reviews in the emerging area of chromatin biology and epigenetic regulation of cardiovascular disease.

Epigenetic processes are known to have powerful roles in organ development across biology. It has recently been appreciated that some of the chromatin modulatory machinery essential for proper development plays a key role in the development of cardiovascular disease in adults. Investigations using genetic and pharmacologic gain and loss of function have interrogated the function of distinct epigenetic regulators, while the increased deployment of the suite of next generation sequencing technologies have fundamentally altered our understanding of the genomic targets of these chromatin modifiers.

The editors encourage submissions addressing key questions such as: To what extent are chromatin regulatory processes truly epigenetic in the adult, and do these processes precede or follow the development of cardiovascular disease phenotypes at the cellular level? What aspects of epigenetic regulation are attributable to histone versus non-histone (and sometimes non-nuclear) substrates of the suite of epigenetic writers, erasers and readers? What secrets of cardiovascular regulation hide in the “non-coding” regions of the genome (e.g. lncRNAs, circRNAs, micropeptides), and what is the molecular basis for their control of gene expression? What are the principles of chromatin structure regulation (heart- and vessel-specific) that have evolved to control cardiovascular cell and organ phenotypes, and how plastic are these structural features in cardiovascular disease? What are the distinct epigenomic programs operative in different cardiovascular cell types such as cardiac myocytes, endothelial cells, fibroblasts, and smooth muscle cells, and how does their derangement precipitate disease? Are epigenetic regulators viable therapeutic targets for cardiovascular disease?

The editors encourage submissions that strive to answer these and other questions in cardiovascular epigenomics, which may have the potential to transform our basic science understanding of how chromatin regulation drives heart and vessel disease. The editors encourage submissions focused on the powerful effects of epigenetic regulators on cardiovascular phenotypes, emerging diagnostic epigenomic measurements, and translational research which may lead to potential new clinical therapies.

We will consider both original research articles and review articles. For review articles only, authors should email the editorial office (khkeehan@verizon.net) a pre-submission inquiry including a working title, author and affiliation lists, abstract, and brief outline of the content for approval by the editors.

All manuscripts should be submitted online at http://ajpheart.msubmit.net/cgi-bin/main.plex. During the online submission process, under the "Keywords & Special Sections" tab, please use the "Category" drop-down menu and select “Call for Papers: Chromatin and Epigenetics in Cardiovascular Disease."

Manuscripts will undergo normal peer review as they are received. Accepted manuscripts will be published online as they are accepted. Articles published from this Call for Papers will be highlighted at the time of publication. All manuscripts accepted from this Call for Papers will be included in an online article collection to further highlight the importance of this topic. The article collection will also include specially commissioned Review articles on the topic.

Manuscripts will undergo normal peer review as they are received. Accepted manuscripts will be published online as they are accepted. Articles published from this Call for Papers will be highlighted at the time of publication. All manuscripts accepted from this Call for Papers will be included in an online article collection to further highlight the importance of this topic. The article collection will also include specially commissioned Review articles on the topic.

Manuscripts can be submitted anytime, but to be eligible for inclusion in this Call for Papers, manuscripts must be submitted by February 15, 2019. If you have any questions please contact Kara Hansell Keehan, Executive Editor, via email at khkeehan@verizon.net.

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