Adaptive Immunity in Cardiovascular Disease

Guest Editors Dr. Kristine Y. DeLeon-Pennell, Dr. Ganesh Halade, and Dr. Daria Ilatovskaya, along with the editorial team of AJP-Heart and Circulatory Physiology, invite submission of original research and short reviews on adaptive immunity in cardiovascular disease.

This Call for Papers focuses on three major components: a) increased understanding of the role of adaptive immunity surrounding adverse cardiovascular events; b) improved definition of the basic mechanisms whereby adaptive immunity act in response to ischemic or non-ischemic cardiovascular disease, and c) establishing relevant interventions to prevent or counteract adverse remodeling in response to injury.

Within the last few decades, a growing number of experimental and clinical studies have been focused on the differential role of macrophages and adaptive immunity in cardiovascular disease. These studies have brought the adaptive immune response to the forefront and shown that T-cells critically influence the disease process by regulating or dysregulating acute or chronic inflammation and fibrosis through cross talk with innate immune cells including macrophages. We encourage manuscript submissions which identify the role of the adaptive immune response in cardiovascular pathophysiology including those studying regulation of macrophage physiology, cardiac remodeling (ischemic and non-ischemic), heart failure, hypertension, and cardiorenal syndrome.

We will consider both original research articles and review articles. For review articles only, authors should email the editorial office ( a pre-submission inquiry including a working title, author and affiliation lists, abstract, and brief outline of the content for approval by the editors.

All manuscripts should be submitted online at During the online submission process, under the "Keywords & Special Sections" tab, please use the "Category" drop-down menu and select “Call for Papers: Adaptive Immunity in Cardiovascular Disease."

Manuscripts will undergo normal peer review as they are received. Accepted manuscripts will be published online as they are accepted. Articles published from this Call for Papers will be highlighted at the time of publication. All manuscripts accepted from this Call for Papers will be included in an online article collection to further highlight the importance of this topic. The article collection will also include specially commissioned Review articles on the topic.

Manuscripts can be submitted anytime, but to be eligible for inclusion in this Call for Papers, manuscripts must be submitted by March 1, 2019. If you have any questions please contact Kara Hansell Keehan, Executive Editor, via email at