The American Physiological Society Press Release

press release logo

APS Contact: APS Communications Office

Email: communications@the-aps.org

Phone: 301.634.7209

Twitter: @APSPhysiology


Losing Just Six Hours of Sleep Could Increase Diabetes Risk, Study Finds

Sleep deprivation alters liver metabolism and fat content

Rockville, Md. (September 5, 2018)—Losing a single night’s sleep may affect the liver’s ability to produce glucose and process insulin, increasing the risk of metabolic diseases such as hepatic steatosis (fatty liver) and type 2 diabetes. The findings of the mouse study are published ahead of print in the American Journal of Physiology—Endocrinology and Metabolism. The research was chosen as an APSselect article for September.

Sleep deprivation has been associated with eating more, moving less and having a higher risk of developing type 2 diabetes. However, a team of researchers from Toho University Graduate School of Medicine in Japan, explained, “It was not clear whether glucose intolerance was due to the changes in food intake or energy expenditure or to the sleep deprivation itself.”

The researchers studied two groups of mice: One group was kept awake for six hours each night (“sleep deprivation”), while the control group was allowed to sleep as desired. The research team offered unlimited high-fat food and sugar water—mimicking lifestyle-related food choices that people make—to both groups prior to the study. During the sleep/wake period, the animals had limited opportunity for physical activity.

The researchers measured glucose levels and fat content of the liver immediately after the trial period. Blood glucose levels were significantly higher in the sleep deprivation group than controls after one six-hour session of wakefulness. Triglyceride (fat) levels and the production of glucose in the liver also increased in the sleep deprivation group after a single wake period. Elevated liver triglycerides are associated with insulin resistance, or the inability of the body to process insulin properly. In addition, lack of sleep changed the expression of enzymes that regulate metabolism in the liver in the sleep deprivation group. These findings suggest that “intervention studies designed to prevent sleep deprivation-induced hepatic steatosis and insulin resistance should be performed in the future,” the researchers wrote.

Read the full article, “Mechanisms of sleep deprivation-induced hepatic steatosis and insulin resistance in mice,” published ahead of print in the American Journal of Physiology—Endocrinology and Metabolism. It is highlighted as one of this month’s “best of the best” as part of the American Physiological Society’s APSselect program. Read all of this month’s selected research articles.

NOTE TO JOURNALISTS: To schedule an interview with a member of the research team, please contact the APS Communications Office or 301-634-7209. Find more research highlights in the APS Press Room.

Physiology is the study of how molecules, cells, tissues and organs function in health and disease. Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 10,500 members and publishes 15 peer-reviewed journals with a worldwide readership.

 


RelatedItems

Type, Not Just Amount, of Sugar Consumption Matters in Risk of Health Problems

Released January 19, 2017 - The type of sugar you eat—and not just calorie count—may determine your risk for chronic disease. A new study is the first of its kind to compare the effects of two types of sugar on metabolic and vascular function. The paper is published ahead of print in the American Journal of Physiology—Heart and Circulatory Physiology.

One Protein, Many Fascinating Roles

Released September 2, 2015 - Endothelin is a peptide produced by cells in the blood vessels and has powerful vessel-constricting effects. Although mainly associated with its role in blood pressure control and cardiovascular diseases, it continues to appear in other physiological functions and diseases. This symposium, taking place at 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics in Savannah, Ga., will discuss its roles in diabetes, cognitive decline, sickle cell disease and skin pigmentation.

Chronic Drinking Disrupts Liver’s Circadian Clock, Contributes to Alcoholic Liver Disease

Released September 10, 2015 - Staying on an internal schedule is important for health, and disease can occur if the body’s internal clock is disrupted. A new study reinforces the importance of circadian rhythm, reporting that chronic drinking contributes to alcoholic liver disease because it impairs the liver’s production schedule of molecules that power it to run.

From: 
Email:  
To: 
Email:  
Subject: 
Message:

~/Custom.Templates/PressRelease.aspx