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Staying Young at Heart: Researchers Convene to Discuss Advances in Healthy Cardiovascular Aging

APS conference to focus on the latest on inflammation, oxidative stress, arterial health and more

Bethesda, Md. (July 26, 2017)—Aging is the No. 1 risk factor for developing cardiovascular disease. With worldwide populations getting older, understanding how to keep the cardiovascular system healthy as we age is imperative. The American Physiological Society (APS) conference “Cardiovascular Aging: New Frontiers and Old Friends” will convene exercise, aging, cardiovascular and other researchers in one place. The conference will be held August 11–14, 2017, in Westminster, Colo.

“At this meeting, we want to better understand and explore the underlying mechanisms that lead to macro-mechanistic processes like inflammation and oxidative stress that affect the function of the cardiovascular system,” said Tony J. Donato, PhD, MS, meeting co-chair and associate professor at the University of Utah. The meeting will bring together leaders in the field—many of whom are funded by the National Institutes of Health—to discuss the implications of aging vascular systems on a host of different physiological systems, organs and tissues.

“We have people from the exercise physiology field, people who have studied basic cellular mechanisms and people who have studied basic vascular physiology. All of those are clearly related, but they often attend different meetings,” said Andreas M. Beyer, PhD, meeting co-chair and assistant professor at the Medical College of Wisconsin. “This meeting will bring those researchers together to advance what we know about the physiological mechanisms that contribute to healthy cardiovascular aging.”

Topics include age-related arterial disease states such as atherosclerosis, hypertension and heart failure. Age-related tissue and systems dysfunction not typically thought to be influenced by vascular function such as cancer, metabolic syndrome and autoimmune disease, will also be discussed.


Friday, August 11

Welcome and Opening Comments        
Andreas Beyer, Medical College of Wisconsin and Anthony Donato, University of Utah

Keynote Lecture: Strategies for Optimal Cardiovascular Aging
Speaker: Douglas Seals, University of Colorado, Boulder

Saturday, August 12

Symposia I: Countermeasures to Cardiovascular Aging
Chairs: Lisa Lesniewski, University of Utah and Amanda Jo LeBlanc, University of Louisville 

Rapamycin and Elamipretide (SS-31): Interventions to Reverse Cardiac Aging by Enhancing Mitochondrial Function
Speaker: Peter Rabinovitch, University of Washington

Late-life Exercise Training Reverses Age-related Microvascular Dysfunction: A Role for Adiponectin
Speaker: Judy Muller-Delp, Florida State University

Modulatory Influences of Sex Hormones on Vascular Aging
Speaker: Kerrie Moreau, University of Colorado, Aurora

Intravenous Adipose-derived Cell Therapy Improves Cardiovascular Performance in Aged Rats
Speaker: Amanda Jo LeBlanc, University of Louisville

Symposia II: Novel Mechanisms of Blood Flow Control and Microvascular Function with Age 
Chair: Frank Dinenno, Colorado State University

Skeletal Muscle Oxygen Transport during Exercise: Effects of Aging and Heart Failure
Speaker: David Poole, Kansas State University

Regulation of Skeletal Muscle Flow during Exercise in Aging Humans
Speaker: Frank Dinenno, Colorado State University

The Impact of Age and Hypertension on Cutaneous Microvascular Function
Speaker: Lacy Alexander, Penn State University

Microvascular Adaptations during Aging: Opportunities for New Models and Discoveries
Speaker: Walter Lee Murfee, Tulane University

Symposia III: Novel Implications for Blood Flow and Vascular Dysfunction in Non-cardiovascular Related Diseases
Chair: Judy Muller-Delp, Florida State University

Implications for Blood Flow in Prostate Cancer
Speaker: Brad Behnke, Kansas State University

Endothelial Dysfunction in the Adipose: A Key Regulator of Age Related Metabolic Dysfunction?
Speaker: Lisa Lesniewski, University of Utah

Sunday, August 13

Plenary Lecture: Blood Pressure Targets for Older Adults: Implications for Cognitive and Cardiovascular Disease Endpoints
Speaker: Mark Supiano, University of Utah

Symposia IV: Novel Mechanisms Underlying Vascular Impairments in the Aging Brain
Chair: Prasad Katakam, Tulane University

Pulse Pressure in the Aging Brain
Speaker: Eric Thorin, University of Montreal

Aging Increases Blood Pressure and Alters the Biomechanical Properties of the Posterior Cerebral Arteries and the Parenchymal Arterioles
Speaker: Anne Dorrance, Michigan State University

Human Cerebral Artery Function and Aging
Speaker: Jill Barnes, University of Wisconsin, Madison

Role of Endothelial nNos in Age-related Microvascular Impairments
Speaker: Prasad Katakam, Tulane University

Symposia V: Cellular Senescence and Genomic Instability: Implications for Cardiovascular Disease
Chair: Anthony Donato, University of Utah

Cellular Senescence and Senolytic Agents in Age-related Dysfunction and Chronic Diseases
Speaker: James Kirkland, Mayo Clinic

Age-related Genomic Instability in Human Arteries
Speaker: Garrett Morgan, University of Utah

Vascular Telomere Dysfunction: Association with Aging and Functional Implications
Speaker: Ashley Walker, University of Utah

Monday, August 14

Symposia VI: Mitochondria: The Epicenter of Aging-related Cardiovascular Defects
Chair: Andreas Beyer, Medical College of Wisconsin

The Requisite Role of Mitochondria in Interactions Between Cardiac Myocytes and the Coronary Vasculature
Speaker: William Chilian, Northeast Ohio Medical University

Oxygen Metabolism, Tissue Responses to Hypoxia, Oxidative Stress, and Molecular Mechanisms of Oxygen Sensing by Mitochondria
Speaker: Paul Schumacker, Northwestern University

Metabolic Regulation of Age-related Mitochondria Defects
Speaker: Changhan David Lee, University of Southern California

Non-canonical Telomerase Signaling as Mechanisms of Mitochondria and Vascular Dysfunction
Speaker: Andreas Beyer, Medical College of Wisconsin

Closing Remarks: Aging and Cardiovascular Diseases: What Is Now, What Is Next?
Speaker: Tony Donato, University of Utah

NOTE TO JOURNALISTS: The Cardiovascular Aging: New Frontiers and Old Friends conference will be held in Westminster, Colo., August 11–14, 2017. To schedule an interview with the conference organizers or presenters, contact the APS Communications Office or call 301-634-7209. Find more research highlights in the APS Press Room.

Physiology is the study of how molecules, cells, tissues and organs function in health and disease. Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 10,500 members and publishes 15 peer-reviewed journals with a worldwide readership.



Strategies to Optimize and Slow Cardiovascular Aging

Released August 11, 2017 - Heart disease remains the leading cause of death in the U.S. and growing older is the greatest—and most inevitable—risk factor for it. So what, if anything, can we do to keep our hearts and arteries as healthy as possible for as long as possible? Keynote speaker Douglas Seals, PhD, of the University of Colorado Boulder, will lay the groundwork of what we know and the promising research that could combat cardiovascular aging in his presentation “Strategies for Optimal Cardiovascular Aging.” Seals will present his lecture at the Cardiovascular Aging: New Frontiers and Old Friends conference in Westminster, Colo.

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Released August 12, 2017 - During the “Novel Implications for Blood Flow and Vascular Dysfunction in Non-cardiovascular Related Disease” symposium at the APS Cardiovascular Aging: New Frontiers and Old Friends conference, researchers will present findings that emphasize the interaction between age-related cardiovascular dysfunction and disease whose risk increases with age.