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Exercise May Shield Against the Health Fallout of a Weeklong Overindulgence

Phoenix (November 3, 2016)—Exercise protects fat tissue from changes in inflammation levels and fat metabolism caused by a week of overeating, a new study finds. University of Michigan researchers will present the results of their study today at the Integrative Biology of Exercise 7 meeting in Phoenix.

Previous studies indicate that as little as one week of overeating can impair glycemic control and insulin sensitivity. But while exercise has been shown to have a protective effect against metabolic impairments caused by eating too much, the specifics of how exercise affects the structure and function of fat tissue are not well understood.

In this pilot study, the researchers studied four lean and active adults who consumed 30 percent more calories than normal for one week. During the experiment, the subjects continued their regular exercise habits (at least 150 minutes of aerobic exercise and at least six days of exercise in the week). The research team measured glucose tolerance and abdominal fat samples before and after the week of overeating.

“Our preliminary findings suggest trends for increases in markers of inflammation (C-reactive protein, pJNK/JNK) after one week of overeating in people who do not exercise,” said Alison C. Ludzki, first author on the study. However, the team found that among the exercising subjects in this study, “overeating did not increase the protein content of markers of adipose tissue inflammation (i.e., pJNK/JNK, pERK/ERK) or circulating C-reactive protein.” The subjects also experienced no change in glucose tolerance or lipolysis (chemical breakdown of fat).

“Our preliminary findings expand on existing work to support a protective role of exercise in the metabolic response of adipose tissue to brief periods of overeating,” the researchers concluded.

Alison C. Ludzki will present “Effects of Exercise on Adipose Tissue Responses to Short-Term Overeating in Healthy Adults” at a poster session on Thursday, Nov. 3, from 5:15 to 715 p.m. in the Atrium Lobby of the Hyatt Regency Phoenix.

NOTE TO JOURNALISTS: The Integrative Biology of Exercise 7 meeting will be held in Phoenix, Nov. 2–4, 2016. Read the full program. To schedule an interview with the conference organizers or presenters, contact the APS Communications Office or call 301-634-7209. Find more research highlights in the APS Press Room.

Physiology is the study of how molecules, cells, tissues and organs function in health and disease. Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 10,500 members and publishes 15 peer-reviewed journals with a worldwide readership.

 


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