The American Physiological Society Press Release

press release logo

APS Contact: Stacy Brooks

Email: sbrooks@the-aps.org

Phone: 301.634.7209

Twitter: @APSPhysiology


Blueberries Show Promise as Treatment for Post-Traumatic Stress Disorder

Boston (March 30, 2015)—Up to 8 percent of people in the U.S. suffer from post-traumatic stress disorder (PTSD) as the result of witnessing or being the victim of a traumatic event. People with PTSD have been in a situation in which they were at risk of death, serious injury or sexual violence or have seen first-hand loved ones faces such threats. They may experience flashbacks, emotional detachment and jumpiness, among other symptoms that affect their ability to function in everyday life.

Currently, the only approved therapy for PTSD is selective serotonin reuptake inhibitors (SSRIs), such as Zoloft and Paxil, but their effectiveness is marginal. Now researchers at Louisiana State University have found that a readily available superfood—the blueberry—could be an effective treatment.

Philip J. Ebenezer will present “The Neuro-Protective Efficacy of Blueberry in an Animal Model of Post-Traumatic Stress Disorder (PTSD)” in a poster session on Monday, March 30, at the Experimental Biology meeting (Boston Convention and Exhibition Center from 12:45 to 3 P.M. EDT).

Ebenezer et al. have previously demonstrated that SSRIs increase levels of serotonin (5-HT) and the neurotransmitter norepinephrine (NE) and that the increased NE may reduce the effectiveness of SSRI therapy. In the new study, the research team looked at the ability of blueberries to modulate neurotransmitter levels in a rat model of PTSD. Researchers supplemented some of the rats with a blueberry-enriched (2 percent) diet and others with a control diet. A third control group did not have PTSD and received a standard diet (without blueberries).

They found that PTSD rats who did not receive blueberries demonstrated a predictable increase in NE and 5-HT when compared with the control group. However, the PTSD rats that received blueberries showed a beneficial increase in 5-HT with no effect on NE levels, suggesting that blueberries can effectively modulate neurotransmitters in PTSD.

Full Abstract

Post-traumatic stress disorder (PTSD) is a trauma and stressor-related disorder that results in a prolonged stress response. It is associated with increased oxidative stress and inflammation in the prefrontal cortex (PFC) and hippocampus (HC). Previous findings from our lab indicate that neurotransmitter levels are modulated in the brain of PTSD animals. The only approved therapy for PTSD is the use of selective serotonin reuptake inhibitors (SSRI), but their efficacy is marginal. Recently, we demonstrated that over-activation of norepinephrine (NE) along with serotonin (5-HT) as the possible reason for the lack of efficacy of SSRI. Hence, there is a need for novel therapeutic approaches for the treatment of PTSD. In this study, we investigated the neuroprotective role of blueberries (BB) in modulating neurotransmitter levels in PTSD. Rats were fed with a blueberry-enriched (2 percent) or a control diet. Rats were exposed to cats for one hour on days 1 and 11 of a 31-day schedule to simulate traumatic conditions. At the end of the study, the rats were euthanized and PFC and HC were isolated. We measured monoamines and their metabolites by high-performance liquid chromatography. In our PTSD model, NE levels were increased and 5-HT levels were decreased when compared to control. In contrast, a BB diet increased 5-HT without affecting NE levels. These findings indicate non-pharmacological approaches might modulate neurotransmitters in PTSD. Further studies to understand the molecular mechanism of neuro-protection by BB can provide a potential therapeutic target for the treatment of PTSD.

NOTE TO JOURNALISTS: To schedule an interview with a member of the research team, please contact Stacy Brooks at sbrooks@the-aps.org or (240) 432-9697.

###

About Experimental Biology 2015

Experimental Biology is an annual meeting comprised of more than 14,000 scientists and exhibitors from six sponsoring societies and multiple guest societies. With a mission to share the newest scientific concepts and research findings shaping current and future clinical advances, the meeting offers an unparalleled opportunity for exchange among scientists throughout the United States and the world who represent dozens of scientific areas, from laboratory to translational to clinical research. www.experimentalbiology.org.

About the American Physiological Society (APS)

Physiology is the study of how molecules, cells, tissues and organs function in health and disease. Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 11,000 members and publishes 14 peer-reviewed journals with a worldwide readership.

Physiology is the study of how molecules, cells, tissues and organs function in health and disease. Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 11,000 members and publishes 14 peer-reviewed journals with a worldwide readership.

 


RelatedItems

Why Gastrointestinal Disorders Afflict Women More Often

Released March 30, 2015 - Women are more likely to have irritable bowel syndrome and other gastrointestinal disorders than men. A new study suggests that it’s because the intestine’s nerve cells are more sluggish in women. Research will be presented at the 2015 Experimental Biology Meeting in Boston on Monday, March 30.

NASA Astronaut-Scientists Speak at APS History of Physiology Group Symposium

Released April 1, 2015 - Astronaut-scientists from the 1998 NASA STS-90 Neurolab space mission will discuss what they learned about how the brain and nervous system work without gravity.

“Ice It.” Why the Ubiquitous Advice Isn’t Healing Your Injury

Released March 30, 2015 - Does icing a serious bruise actually speed recovery time and assist in muscle repair? Researchers say no. Study results to be presented at the 2015 Experimental Biology Meeting in Boston on Monday, March 30.

Diet Rich in Methionine—Found Most Abundantly in Eggs, Fish and Meats—May Promote Memory Loss

Released March 31, 2015 - Eating mostly protein in your diet? Research suggests a diet rich in eggs, fish and meats can lead to memory loss. Research will be presented at the 2015 Experimental Biology Meeting in Boston on Tuesday, March 31.

On the Edge of Extinction: Tiny Pupfish Go without Breathing to Survive their Harsh Environment

Released March 31, 2015 - The endangered desert pupfish has made itself at home in the harsh, hot environment of Death Valley hot springs by using a surprising evolutionary adaptation: They can go for up to five hours without oxygen. Research will be presented at the 2015 Experimental Biology Meeting in Boston on Tuesday, March 31.

From: 
Email:  
To: 
Email:  
Subject: 
Message:

~/Custom.Templates/PressRelease.aspx