The American Physiological Society Press Release

press release logo

APS Contact: APS Communications Office

Email: communications@the-aps.org

Phone: 301.634.7209

Twitter: @APSPhysiology


Gastric Bypass Surgery Improves Blood Sugar Handling and Insulin Sensitivity, Study Find

Bethesda, Md. (October 5, 2015)—Roux-en-Y, the most common type of gastric bypass surgery, can lead to remission of type 2 diabetes along with weight loss. A new study in the American Journal of Physiology—Regulatory, Integrative and Comparative Physiology examines why, finding that insulin sensitivity of the main glucose (sugar) storage sites in the body improve after gastric bypass surgery.

Insulin is the primary hormone responsible for transferring glucose from the blood stream into the body’s tissues to be used by the cells or stored. The skeletal muscles and fat tissues are the main glucose storage sites in the body. How readily the body responds to insulin, called insulin sensitivity, indicates how quickly glucose can be transferred out of the blood. Poor insulin sensitivity slows the uptake of glucose into the skeletal muscle and fat tissues and leads to a high blood sugar level. Decreased insulin sensitivity is common in people with obesity and type 2 diabetes.

Abdominal fat and thigh muscle samples were taken from obese patients with type 2 diabetes and obese patients with normal glucose control before and after gastric bypass surgery. All patients showed substantial weight loss and improved insulin sensitivity by 12 months after surgery. Levels and activities of insulin-controlled proteins increased in both fat and muscle tissues after gastric bypass surgery, changes that enhance insulin sensitivity. Fat tissue from non-diabetic patients showed the most changes compared with diabetic patients, while changes in skeletal muscle were similar.

The data suggest that improved insulin sensitivity in the skeletal muscle and fat tissue contribute to the improved whole-body insulin action following gastric bypass surgery. These adaptations were observed only after significant weight loss had occurred, the research team noted. Interestingly, improvement in insulin sensitivity was associated with changes in fat tissue rather than skeletal muscle, suggesting that fat tissue may play a larger role in insulin sensitivity than currently believed, the team wrote. The study was performed by researchers from the University of Copenhagen in collaboration with Novo Nordisk A/S, Hvidovre Hospital and Aarhus University in Denmark.

The article “Enhanced insulin signaling in human skeletal muscle and adipose tissue following gastric bypass surgery” is published in the American Journal of Physiology—Regulatory, Integrative and Comparative Physiology. It is highlighted as one of this month’s “best of the best” as part of the American Physiological Society’s APSselect program. Read all of this month’s selected research articles on the APSselect site.

NOTE TO JOURNALISTS: To schedule an interview with a member of the research team, please contact the APS Communications Office or 301-634-7209. Find more research highlights in the APS Press Room.

Physiology is the study of how molecules, cells, tissues and organs function in health and disease. Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 10,500 members and publishes 15 peer-reviewed journals with a worldwide readership.

 


RelatedItems

Health Improvements after Gastric-Bypass Surgery Start Well before Dramatic Weight Loss Begins

Released April 6, 2016 - New research presented at the Experimental Biology 2016 meeting suggests that fat and blood sugar control and cardiovascular health start improving in the early stages of recovery before dramatic weight loss occurs.

Weight Loss from Gastric Bypass Partly Due to Dietary Fat Aversion

Released July 27, 2011 - A study in people and rats, published by the APS, suggests that gastric bypass doesn’t just cut calories – it may also cause patients to have an aversion to dietary fat.

Exercise Helps Ease Premature Cardiovascular Aging Caused by Type 2 Diabetes

Released October 10, 2012 - Exercise helps ease the premature cardiovascular aging that type 2 diabetes can cause.

Lap Band Gastric Bypass Surgery Improves Insulin Resistance

Released May 1, 2007 - A new study examining the overall and gender-related effects of laparoscopic gastric banding surgery on insulin resistance, body composition, and metabolic risk markers six months after surgery has found significant improvements in insulin resistance.

From: 
Email:  
To: 
Email:  
Subject: 
Message:

~/Custom.Templates/PressRelease.aspx