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Physiological Bioenergetics Meeting Focuses on Power Plant of Cells: The Mitochondria

Researchers Gather to Discuss Cross-Discipline Mitochondrial Mechanisms

Bethesda, Md. (August 13, 2015)The American Physiological Society (APS) will host the “Physiological Bioenergetics: From Bench to Bedside” conference September 9–12, 2015, in Tampa, Fl. The second in the APS fall conference series, this meeting will assemble cross-disciplinary experts who study mitochondrial function and its regulatory mechanisms, with a special emphasis on translational and physiological mechanisms.

The importance of the mitochondria in cell metabolism and signaling is emerging as an active and critical area of bioenergetics research and is a focus for the symposia presented at this conference. In recent years, new cutting-edge technologies, molecular tools and targeted therapies have dramatically altered the study of bioenergetics under physiological conditions, allowing researchers to better understand mitochondrial function. 

“Over the last 20 to 30 years, it’s become apparent that mitochondria perform a multitude of functions to maintain cellular homeostasis, all of which are intimately linked to both metabolic and genomic programs, extending well beyond simply making adenosine triphosphate (ATP),” said conference organizer Victor M. Darley-Usmar, PhD. “The goal of this meeting is to bring together experts who study varied facets of bioenergetics across disciplines and in the context of different pathologies to share their most recent findings and to discuss strategies to advance the field of ‘mitochondriology’ into translational and clinical studies.” The conference organizing committee anticipates an exciting meeting bringing together bioenergetics experts, junior investigators, graduate students and postdoctoral fellows.

Program Highlights

Wednesday, September 9, 2015

Opening Plenary Lectures: 

“The Ongoing Evolution of the Mitochondrial Paradigm of Disease” 
Plenary Speaker: Doug Wallace, Children’s Hospital of Philadelphia 

“Variants of Mitophagy: Type 1, Type 2 and Micromitophagy (Type 3)
Plenary Speaker: John LeMasters, Medical University of South Carolina, Charleston

Thursday, September 10, 2015

Symposia I: Energy School I 

“Integrating Mitochondrial Activity Measurements with High Resolution Central Carbon Metabolomics Data” 
Speaker: Brad Hill, University of Louisville 

“How to Measure Autophagy and Mitophagy” 
Speaker: Jianhua Zhang, University of Alabama at Birmingham

Symposia II: Mitochondria on the Move: Networking in Health and Disease 

“Targeting Mitochondrial Fission for Oxidative Pathology” 
Speaker: Yisang Yoon, Georgia Regents University 

“Mitochondrial Autophagy and Biogenesis: The Cycle of Life” 
Speaker: Roberta Gottlieb, San Diego State University

“Mitochondrial Motility and Fusion Dynamics and Calcium” 
Speaker: Gyorgy Hajnoczky, Thomas Jefferson University 

Career Session: How to Succeed: A Research Scientist and Entrepreneur in Bioenergetics
Panelists: Brian Dranka, Seahorse Bioscience 
                 Gary Glick, Lycera Corporation

Plenary Lecture: “Sites of Production of Mitochondrial ROS: Mechanisms and Physiological Function” 
Plenary Speaker: Martin Brand, Buck Institute for Research on Aging

Symposia III: Translational Bioenergetics 

“Measuring Bioenergetic Health in Human Populations” 
Speaker: Victor Darley-Usmar, University of Alabama at Birmingham 

“Platelet Mitochondria: From Biomarker to Biological Mechanism in Sickle Cell Patients” 
Speaker: Sruti Shiva, University of Pittsburgh 

“Mitochondrial Biomarkers for Neurodegenerative Diseases” 
Speaker: Russ Swerdlow, University of Kansas 

“Translational Bioenergetics in Cancer” 
Speaker: Brian Dranka, Seahorse Bioscience 

“Using Machine Learning to Advance Blood-Based Bioenergetic Profiling: A Focus on Geriatric Health”
Speaker: Anthony Molina, Wake Forest Baptist Medical Center

Friday, September 11, 2015

Symposia IV: Energy School II 

“The Latic Acidosis Consortium: A Multidisciplinary Research Effort to Translate Gene Discovery into Better Management and Treatment for Patients with Mitochondrial Disorders” 
Speaker: Yan Burelle, University of Montreal, Canada

“Mitochondrial DNA Content: Accurate Measurement and Evaluation as an Early Biomarker of Mitochondrial Dysfunction” 
Speaker: Afshan Malik, Kings College, London, UK

Symposia V: Mitochondrial Adaptation and Susceptibility to Stress 

“Mitochondrial Function in Innate Immunity: Mechanisms and Therapeutic Potential” 
Speaker: Gary Glick, Lycera Corporation

“A Unifying Hypothesis for the Mitochondrial Contribution to Ischemia-Reperfusion” 
Speaker: Paul Brookes, University of Rochester 

“Mitochondrial Fuel Substrate Switching and the Excitable Brain” 
Speaker: Nika Danial, Dana Farber Cancer Institute

Plenary Lecture: “The Sugar Disconnection in Diabetic Mitochondrial Networks” 
Plenary Speaker: Orian Shirihai, Boston University

Symposia VI: It’s Not Just the ATP! Signaling and Mitochondrial Function 

“Mitochondria Matter: Targeting Mitochondrial Function in Tumor Cells” 
Speaker: Ben van Houten, University of Pittsburgh 

“Tick, Tock: The Biological Clock Controls the Powerhouse” 
Speaker: Shannon Bailey, University of Alabama at Birmingham 

“Mitochondrial Telomerase and Vasodilation” 
Speaker: Andreas Beyer, Medical College of Wisconsin 

Saturday, September 12, 2015

Symposia VII: Mitochondrial Genetic and Metabolic Programs 

“Novel Signaling Peptides from the Mitochondrial Genome” 
Speaker: Changhan David Lee, University of Southern California, Los Angeles 

“Mitochondrial Nuclear Genetic Cross Talk and Disease: Mito-Mendelian Genetics” 
Speaker: Scott Ballinger, University of Alabama at Birmingham 

“The Crosstalk Between Mitochondrial Function, the Epigenetics and Gene Expression” 
Speaker: Janine Santos, National Institute of Environmental Health Sciences, NIH 

“Bioenergetics, Stem Cells and Hypoxia” 
Speaker: Hannele Ruohola-Baker, University of Washington

NOTE TO EDITORS: Physiological Bioenergetics: From Bench to Bedside (#Bioenergetics15) will be held September 9–12 in Tampa, Fl. The press is invited to attend. Please contact APS Communications for additional information.

Physiology is the study of how molecules, cells, tissues and organs function in health and disease. Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 10,500 members and publishes 15 peer-reviewed journals with a worldwide readership.



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