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Endothelin-14 Conference to Present Cutting-Edge Therapeutic and Disease Findings

Leading global researchers in cardiovascular disease, diabetes and cancer to attend  

Bethesda, Md. (August 6, 2015)—The American Physiological Society is proud to host the 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics September 2–5 in Savannah, Ga. The meeting will convene leading global researchers who study endothelin—a type of powerful peptide that constricts blood vessels, raises blood pressure and controls many other cellular functions throughout the body. When endothelin peptides are overexpressed, they can contribute to high blood pressure, cardiovascular disease and other vascular and non vascular health problems, such as diabetes, sickle cell anemia and kidney disease.

 "A fascinating aspect of this meeting is that it includes a strong representation from the pharmaceutical industry, including individuals who have been pioneers in developing new drugs for the treatment of diverse disorders, such as pulmonary hypertension, diabetic nephropathy, cancer and others,” said David Pollock, PhD, one of the conference organizers. “The bulk of the meeting is based on submitted abstracts, so much of the latest research in endothelin will be presented. This year’s meeting also includes a session devoted specifically to the development of new state-of-the-art therapies.”

Program Highlights

Friday, September 4, 2015

Symposia I: Endothelin Synthesis and Receptor Behavior
Keynote Speaker: Janet Maguire, University of Cambridge, UK
“New Insights in ET Receptor Pharmacology”

Symposia II: The Immune System and Endothelin
Keynote Speaker: David Harrison, Vanderbilt University School of Medicine
“Inflammation, Immunity and Hypertension”

Symposia III: ET, Sex and Pregnancy
Keynote Speaker: Jennifer Sullivan, Georgia Regents University
“Sex and Hypertension”

Symposia IV: Roles of ET-1 on Vascular Function and Diseases
Keynote Speaker: Noriaki Emoto, Kobe University Graduate School of Medicine, Kyoto, Japan
“ET-1 in the Heart in Health Disease

Symposia V: Endothelin and Diabetes and Metabolism
Keynote Speaker: John Pernow, Karolinska Institutet, Stockholm, Sweden
“Endothelin and Diabetic Complications”

Symposia VI: Endothelin-1 and Angiogenesis
Keynote Speaker: Anton H. van den Meiracker, Erasmus University Medical Center, Rotterdam, the Netherlands
“ET and Anti-angiogenic Therapy

Symposia VII: ET-1 in the Kidney
Keynote Speaker: Neeraj Dhaun, University of Edinburgh, UK
“ET Therapy in Kidney Disease”

Symposia VIII: Exercise and Pulmonary Function

Saturday, September 5, 2015

Symposia IX: Central Nervous System and Pain
Keynote Speaker: Wolfgang Liedtke, Duke University Medical Center
“Mechanisms of ET in Pain”

Symposia X: Neurovascular Coupling
Keynote Speaker: Constantino Iadecola, Weill Cornell Medical College
“ET and Neurovascular Coupling”

Symposia XI: Endothelin Therapeutics—Where Are We?

Anna Bagnato, Regina Elena National Cancer Institute, Istituti Fisioterapici Ospitalieri, Rome, Italy
“Endothelin Therapeutics in Cancer—Where Are We?”

Donald Kohan, University of Utah Health Sciences Center
“Endothelin Antagonists in Diabetic Nephropathy”

Pierre-Louis Tharaux, French Institute of Health and Medical Research (INSERM), Paris, France
“Endothelin Receptor Antagonism in Sickle Cell Nephropathy”

Radko Komers, Retrophin Inc.
“Combined AT1 and ETA Blockade”

Martine Clozel, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland
“Endothelin Research and Drug Recovery”

NOTE TO EDITORS: The 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics (#Endothelin14) will be held September 2–5 in Savannah, Ga. The press is invited to attend. Please contact APS Communications for additional information.

Physiology is the study of how molecules, cells, tissues and organs function in health and disease. Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 10,500 members and publishes 15 peer-reviewed journals with a worldwide readership.



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