The American Physiological Society Press Release

press release logo

APS Contact: Stacy Brooks


Phone: 301.634.7209

Twitter: @APSPhysiology

Tumors Prefer the Easy Way Out

Study sheds new insights into how cancers spread

Bethesda, Md. (April 16, 2015)—Tumor cells become lethal when they spread. Blocking this process can be a powerful way to stop cancer. Historically, scientists thought that tumor cells migrated by brute force, actively pushing through whatever tissue was in their way, but recent evidence has shown that tumor cells may be more methodical. And in a new study, Cornell University researchers report that tumor cells take advantage of already-cleared paths to migrate unimpeded.

“We are looking for novel ways of preventing cancer cells of the primary tumor from spreading to other parts of the body.  Our study points to potential therapeutic targets that could be inhibited to halt tumor cell movement,” says principal investigator Cynthia Reinhart-King, PhD.

The body’s tissue is full of small gaps in between the different proteins and cells that make it up. Much of the research into tumor cell migration, however, has represented the tissue as a solid gel. While this model has been useful in understanding how tumor cell invade, scientists are not sure if moving through an environment with non-uniform consistency, like the body, involves the same machinery. Some studies have supported that preexisting spaces and tracks join together into tunnels that tumor cells can use to migrate and spread.

In this new study, the research team examined how tumor cells moved through a more accurate model of the tissue environment that included cell-sized tracks compared with a uniform environment with no paths. “Numerous groups, including our own, have studied how cells move.  We now know, however, that how cells move depends on the structure of the environment in which they are moving. Ours is the first study to rebuild the native tracks and gaps that exist in tissue to investigate how cells use these as superhighways to move quickly to spread throughout the body,” says Reinhart-King.

The investigators found that when working through an environment with no pre-existing tracks, tumor cells had to actively stick to the tissue, break it down and then move themselves forward. In contrast, moving through tissue with paths was much easier because once the cells found the tunnels, they could avoid their tissue-clearing processes and pass through unhampered.

These findings support that tumor cells prefer pre-formed tunnels because they allow the cells to move easier. The study also suggests that targeting the machinery that makes cells mobile, rather than targeting the tissue-clearing process—which has been tested in patients but has not been very effective—may be a better treatment strategy to stop cancers from spreading.

The article “Comparative mechanisms of cancer cell migration through 3D matrix and physiological microtracks” is published in the American Journal of Physiology—Cell Physiology. It is highlighted as one of this month’s “best of the best” as part of the American Physiological Society’s APSselect program. View the full study: Read all of this month’s selected research articles at

NOTE TO JOURNALISTS: To schedule an interview with a member of the research team, please contact Stacy Brooks at or 301-634-7253.

Physiology is the study of how molecules, cells, tissues and organs function in health and disease. Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 10,500 members and publishes 15 peer-reviewed journals with a worldwide readership.



Cancer Drug Encourages Both Disease Regression and Loss of Taste

Released March 2, 2015 - Researchers at the University of Michigan have identified the pathway responsible for taste changes among users of chemotherapy drugs that treat basal cell carcinoma. Manuscript was chosen as an APSselect article for March.

Endothelin-14 Conference to Present Cutting-Edge Therapeutic and Disease Findings

Released August 6, 2015 - APS will host the 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics on September 2–5 in Savannah, Ga. The meeting will convene leading global researchers who study endothelin—a type of powerful peptide that constricts blood vessels, raises blood pressure and controls many other cellular functions throughout the body.

International Experts Talk Cancer, Sickle Cell, Diabetic Nephropathy Therapies at Endothelin Meeting in Savannah

Released September 2, 2015 - Endothelin (ET) plays a role in many functions throughout the body, including blood vessel constriction and blood pressure regulation and in a number of disease pathologies. Insights gained through the study of ET have great therapeutic potential for health and disease. As ET experts convene for the 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics, the translational aspect of ET research will take center stage during the “Endothelin Therapeutics—Where Are We?” symposium.