Still a Champion Runner at 80: Do Elite Athletes Have an Anti-Aging Secret in Their Muscles?
Released December 22, 2015 - Elite runners do not experience the muscle weakening associated with aging as non-athletes do. A new study published in American Journal of Physiology—Cell Physiology examines if their superb fitness is because their muscles have not aged.
Carbs, Not Fats, Boost Half-Marathon Race Performance, Study Finds
Released December 15, 2015 - Recent studies have proposed that burning fat instead of carbohydrates will improve exercise performance because the body's fat reserve is much larger than its carbohydrates reserve. A new study in Journal of Applied Physiology reports the opposite, finding that muscles rely on carbohydrates as their fuel source during prolonged exercise.
Study Links Environmental and Lifestyle Factors to Reproductive Problems, Infertility in Men
Released December 10, 2015 - Environmental and lifestyle factors are damaging men’s reproductive health and may be playing a large role in decreasing fertility rates in industrialized countries, a new study in Physiological Reviews reports. Socioeconomic influences and female reproductive health cannot solely be blamed for higher incidences of infertility, the study supports.
Study Suggests New Strategy for Treating Rare Neurodegenerative Disorder Menkes Disease
Released December 1, 2015 - Menkes disease arises from dysfunction in ATP7A, a protein that transports copper to cells, leading to brain development complications. Introducing working versions of ATP7A in the brain is considered the most direct therapeutic approach. However, a new study in AJP-Cell suggests that functioning ATP7A located elsewhere in the body, not necessarily the entire brain, can help treat the disorder. This research is highlighted as one of this month’s “best of the best” as part of the American Physiological Society’s APSselect program.
When Exercise Is Unhealthy for the Heart: Researchers Describe How Heart Problems and Sudden Cardiac Death Occur with Endurance Exercise
Released November 25, 2015 - Endurance exercise accelerates the development of heart problems in individuals with a particular genetic mutation, a new study finds. In mice with a mutated version of desmoplakin, a protein that maintains the heart wall, exercise made the heart walls come apart sooner. The findings offer insight into how to best manage exercise in individuals with the mutation.
New Biomarker Predicts Development of Preeclampsia at Six Weeks of Pregnancy
Released November 20, 2015 - Preeclampsia is generally diagnosed later in pregnancy, but new research reports that the protein copeptin can predict the development of preeclampsia as early as six weeks of gestation. The findings could lead to diagnosis of the disorder in the first trimester, improving care and potentially leading to the development of preventative measures.
Children Born to Women after Bariatric Surgery at Higher Risk of Obesity, Diabetes
Released November 19, 2015 - Weight-loss surgery can boost fertility in women and reduce the risk of pregnancy complications that commonly occur in obese women. However, a new study in rats suggests that weight-loss surgery alters mothers’ hormone and chemical balance, which harms offspring during gestation and later in life.
Sex Reassignment Surgery May Be Better for Transgender Women’s Health than Hormones Only
Released November 18, 2015 - Transgender women may be at a higher risk of developing cardiovascular disease and type 2 diabetes compared with men and women in the general population. New research finds that transgender women who received only hormone therapy had poorer metabolic health than transgender women who underwent sex reassignment surgery in addition to receiving hormone therapy, suggesting that sex reassignment surgery may be metabolically protective.
Is Testosterone Therapy Safe?
Released November 18, 2015 - The increasing use of testosterone replacement therapy to treat reduced testosterone level in older men has been accompanied by growing concerns over its long-term safety. Two studies examining the health risks of receiving testosterone will be presented at Cardiovascular, Renal and Metabolic Diseases: Physiology and Gender conference, supporting opposite conclusions regarding risks.
Male Hormone Testosterone Cause of Sex Differences in Parkinson’s Disease Risk, Study Suggests
Released November 18, 2015 - Men are twice as likely as women to develop Parkinson’s disease. New research suggests that testosterone enhances the susceptibility of brain cells that control movement to damage from chemical imbalances, explaining the sex differences in the occurrence of Parkinson’s.
Genes May Determine the Side Effects of Menopausal Hormone Therapy, Study Suggests
Released November 10, 2015 - Cardiovascular disease risk in women increases after menopause and is associated with the drop in estrogen levels. Menopausal hormone therapy could slow the progression, but oral formulations also increase the risk of blood clots. A new study reports that whether a woman will obtain cardiovascular benefits from certain types of hormone therapy may depend on her genes.
Diet Lacking Soluble Fiber Promotes Weight Gain, Mouse Study Suggests
Released October 30, 2015 - A new study in American Journal of Physiology--Gastrointestinal and Liver Physiology highlights the importance of the gut microbiome in maintaining intestinal and metabolic health and suggests that eating more foods high in soluble fiber may help prevent metabolic disease and obesity. This research is highlighted as one of this month’s “best of the best” as part of the American Physiological Society’s APSselect program.
Novo Nordisk Foundation Continues Support of APS Awards
Released October 28, 2015 - The Foundation will provide $100,000 over five years toward August Krogh Lecture and Bodil Schmidt-Nielsen Award. The awards are named in honor of physiologists August Krogh and Bodil Schmidt-Nielsen, who have made significant contributions to the field and also have unique ties to the Novo Nordisk Foundation and The American Physiological Society.
Clumsy? Ballet Might Help
Study in professional ballet dancers finds that ballet training may improve balance and coordination in daily activities.
New Study Explains Why You Bulk Up with Resistance Training, Not Endurance Training
Released October 20, 2015 - Research published in Physiological Reports shows that resistance and endurance exercises activate the same gene, PGC-1a, but the processes stimulated for the muscles to adapt depend on the exercise type. The study offers insight into why the physical changes from resistance exercise are so different than from endurance exercise.
Physiology and Gender Conference to Present Latest Research on Sex Differences in Disease Risk
Released October 13, 2015 - APS will host the Cardiovascular, Renal and Metabolic Diseases: Physiology and Gender conference Nov. 17–20, in Annapolis, Md. This meeting will bring together leading scientists studying the influence of sex and gender on cardiovascular, kidney and metabolic health and disease.
Gastric Bypass Surgery Improves Blood Sugar Handling and Insulin Sensitivity, Study Finds
Released October 5, 2015 - Gastric bypass surgery can lead to remission of type 2 diabetes along with weight loss. A new study examines why, finding that insulin sensitivity of the body's main glucose (sugar) storage sites improve after gastric bypass surgery.
Lung Disease May Increase Risk of Insulin Resistance, Diabetes, Mouse Study Suggests
Released September 30, 2015 - Numerous studies have identified obesity and poor diet as risk factors for insulin resistance and diabetes. Now, a new study adds another risk factor to the list: inflammatory lung disease. The article is published ahead-of-print in the AJP - Regulatory, Integrative and Comparative Physiology.
Age, Not Post-Op Infection, More Important for Kidney Transplant Success, Study Finds
Released September 22, 2015 - Infection by virus cytomegalovirus (CMV) is a major complication following kidney transplantation. CMV infection has been associated with increased kidney transplant failure and reduced patient survival. However, a new clinical study finds that age may be more important for long-term transplant and patient outcome.
For Veterans with Gulf War Illness, an Explanation for the Unexplainable Symptoms
Released September 10, 2015 - One in four Gulf War veterans suffers from Gulf War Illness, a condition characterized by unexplainable chronic fatigue, muscle pain and cognitive dysfunction. New research finds for the first time direct evidence that the cells of Gulf War veterans cannot produce enough energy to run the body, explaining the fatigue and slow down of the body.
Mechanical Ventilators: From Breathing Help to Breathing Handicap
Released September 10, 2015 - Researchers explore cell-level changes that weaken the diaphragm after prolonged ventilator use Abstract: Mechanical ventilators are routinely used in both surgical and emergency situations every day in U.S. hospitals. Though often life saving in the short term, prolonged use of ventilators can lead to diaphragm weakness, and problems commonly arise—roughly 20 to 30 percent of the time—when weaning the patient off of the ventilator. In a new study, researchers at the University of Florida provide insights into what causes the weakness on a cellular level. Their result could lead to strategies that hospitals can use to help prevent ventilator-related diaphragm damage.
High-Intensity Training Delivers Results for Older Men—But Not for Older Women
Released September 10, 2015 - High intensity training (HIT) is often recommended as a way to improve cardiovascular fitness in men and women, however, studies on these exercise regimens have focused on younger subjects. University of Copenhagen researchers looked at HIT effects in older males and females and found significant differences between men and women. They presented their results at the Physiological Bioenergetics conference in Tampa, Fla.
Chronic Drinking Disrupts Liver’s Circadian Clock, Contributes to Alcoholic Liver Disease
Released September 10, 2015 - Staying on an internal schedule is important for health, and disease can occur if the body’s internal clock is disrupted. A new study reinforces the importance of circadian rhythm, reporting that chronic drinking contributes to alcoholic liver disease because it impairs the liver’s production schedule of molecules that power it to run.
Could the Bioenergetic Health Index Become the Next BMI?
Released September 9, 2015 - A number of chronic diseases that have widespread effects on worldwide populations, such as cancer, neurodegeneration and cardio-metabolic syndromes, are known to have a connection to mitochondrial bioenergetics, the process by which cells create and use energy. “The bioenergetic health of an individual or group can serve as an early warning or the ‘canary in the coal mine’ to determine those with susceptibility to pathologies which stress the mitochondrion. It is clear that we urgently need new clinical tests to monitor changes in bioenergetics in patient populations,” said Victor Darley-Usmar of the University of Alabama at Birmingham and organizer for the “Physiological Bioenergetics: From Bench to Bedside” conference. The bioenergetic health index has the potential to be a new biomarker for assessing patient health for both prognostic and diagnostic value.
IV Administration of Endothelin B Receptor Drug Reduces Memory Loss, Oxidative Stress in Alzheimer’s Disease
Released September 4, 2015 - An estimated 5.3 million people in the U.S. suffer from Alzheimer’s disease (AD). The five current FDA-approved AD medications only help mask the disease symptoms instead of treating the underlying disease. In a new study presented at the 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics, researchers used IRL-1620, a chemical that binds to endothelin B receptors, to treat AD in rats.
International Experts Talk Cancer, Sickle Cell, Diabetic Nephropathy Therapies at Endothelin Meeting in Savannah
Released September 2, 2015 - Endothelin (ET) plays a role in many functions throughout the body, including blood vessel constriction and blood pressure regulation and in a number of disease pathologies. Insights gained through the study of ET have great therapeutic potential for health and disease. As ET experts convene for the 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics, the translational aspect of ET research will take center stage during the “Endothelin Therapeutics—Where Are We?” symposium.
Vitamin C: The Exercise Replacement?
Released September 4, 2015 - Exercise improves health in overweight and obese adults but can be hard to incorporate into a daily routine. New findings show that taking vitamin C supplements daily instead can have similar cardiovascular benefits as regular exercise in these adults. This study will be presented at 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics in Savannah, Ga.
New Hope for Lou: Unexplored Therapeutic Targets for ALS
Released September 3, 2015 - No cures exist for amyotrophic lateral sclerosis (ALS), and the only approved therapy slows the progression by only a few months. A new study identifies a promising unexplored avenue of treatment for ALS, the endothelin system. This study will be presented at 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics in Savannah, Ga.
One Protein, Many Fascinating Roles
Released September 2, 2015 - Endothelin is a peptide produced by cells in the blood vessels and has powerful vessel-constricting effects. Although mainly associated with its role in blood pressure control and cardiovascular diseases, it continues to appear in other physiological functions and diseases. This symposium, taking place at 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics in Savannah, Ga., will discuss its roles in diabetes, cognitive decline, sickle cell disease and skin pigmentation.
CPAP Works: Common Sleep Apnea Treatment Reverses Brain Function Changes Associated with Heart Disease
Released September 1, 2015 - CPAP machines are a common treatment for obstructive sleep apnea, but some people have a hard time adjusting and do not continue the treatment or are reluctant to start. A new study shows that CPAP is an effective sleep apnea treatment, finding that it reverses health changes that result in cardiovascular disease if the disorder is left untreated. This study is highlighted as one of this month’s “best of the best” as part of the APSselect program.
This Week’s Articles in PresS Highlights
Released August 27, 2015 - Articles on the solution used to culture test-tube embryos and its role in future increased cardiovascular disease risk and the involvement of the Y chromosome in male disease and immune function are featured.
This Week’s Articles in PresS Highlights
Released August 19, 2015 - New treatments for fibromyalgia and a dairy-derived protein discovered to be a prebiotic that holds promise for treating gastrointestinal conditions and obesity are featured this week.
New Research Shows Why Statins Should Be Viewed as a Double-Edged Sword
Released August 13, 2015 - Statins have significant cardiovascular benefits, but also serious side effects. A new study finds that statin use impairs stem cell function, which helps in slowing atherosclerosis but hinders other body processes. Because of these effects, the study supports weighing individual risk when considering statins as a preventive measure.
Physiological Bioenergetics Meeting Focuses on Power Plant of Cells: The Mitochondria
Released August 13, 2015 - The second in the APS fall conference series, this meeting will assemble cross-disciplinary experts who study mitochondrial function and its regulatory mechanisms, with a special emphasis on translational and physiological mechanisms.
Endothelin-14 Conference to Present Cutting-Edge Therapeutic and Disease Findings
Released August 6, 2015 - APS will host the 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics on September 2–5 in Savannah, Ga. The meeting will convene leading global researchers who study endothelin—a type of powerful peptide that constricts blood vessels, raises blood pressure and controls many other cellular functions throughout the body.
Resuming Exercise Soon After Heart Attack Can Improve Heart Recovery
Released August 3, 2015 - Many lifestyle factors cause heart disease, and exercise may not be enough to prevent heart attacks. A new study shows that regular exercise can still benefit the heart after a heart attack occurs. This research is highlighted as one of this month’s “best of the best” as part of the American Physiological Society’s APSselect program.
This Week’s Articles in PresS Highlights
Released July 23, 2015 - How the components of the Mediterranean lifestyle—with the exception of wine—work to combat cardiovascular disease risk and how drinking more beet juice can improve exercise performance and lengthen workouts are featured this week.
This Week’s Articles in PresS Highlights
Released July 15, 2015 - The link between PTSD and cardiovascular disease and treating liver cirrhosis with diabetes drug metformin are featured this week.
Can Four Fish Oil Pills a Day Keep the Doctor Away? For Healthy Seniors, Perhaps
Released July 6, 2015 - Omega-3 fish oil is a popular supplement because of its perceived cardiovascular benefits, but the scientific evidence has been conflicting. New research in Physiological Reports supports the claims for seniors, finding that healthy seniors who took omega-3 supplements every day had better cardiovascular health after 12 weeks of use.
July APSselect Research Highlights
Released July 1, 2015 - Brown adipose transplantation reverses type 1 diabetes in mice; heme oxygenase system as a potential therapeutic strategy for cardiovascular diseases; benefits of caloric restriction for muscle metabolism and mass during middle age; muscle signature of a champion sprinter are among this month’s selected articles.
Electrical Nerve Stimulation Can Reverse Spinal Cord Injury Nerve Damage in Patients
Released July 1, 2015 - Researchers find that nerve stimulation can improve the function of peripheral nerves damaged by spinal cord injury (SCI). This technique may be a new approach to preventing long-term changes in nerve and muscle function after SCI and improving SCI rehabilitation outcomes.This research is highlighted as one of this month’s “best of the best” as part of the American Physiological Society’s APSselect program.
Promising New NSAID-Derivative May Be Well-Tolerated by Chronic Pain Sufferers
Released July 1, 2015 - Long-term use of naproxen (ALEVE), a type of nonsteroidal anti-inflammatory drugs (NSAIDs), is often prescribed for chronic pain conditions such as osteoarthritis. However, because of NSAID-related gastrointestinal problems including stomach and intestinal inflammation and ulcers, many are unable to tolerate ongoing use. A new study, published in the American Journal of Physiology–Gastrointestinal and Liver Physiology, finds that a naproxen-derivative may provide both symptom relief and gastrointestinal protection. The research is highlighted as one of this month’s “best of the best” as part of the American Physiological Society’s APSselect program.
Why the Bloating During Menopause? Blame the Hormones or the Lack of Them
Released June 22, 2015 - Many women experience water retention and bloating when their hormone levels change, but how sex hormones affect water balance is not understood. A new study offers an explanation, finding that sex hormones can directly control how the body reabsorbs water.
Better than Stem Cells: Researchers Develop a Faster Way to Treat the Heart after a Heart Attack
Released June 16, 2015 - For healing the heart after a heart attack, stem cell therapies show promise but are slow to implement. Researchers develop a new treatment called microsphere therapy that can be kept on-hand and administered more readily than stem cells.
Polycystic Ovary Syndrome and Diabetes: Researchers Find Out Why the Two Are Linked
Released June 4, 2015 - Nearly 50 percent of women with polycystic ovary syndrome (PCOS) develop pre-diabetes or type 2 diabetes before the age of 40, but the reasons for the correlation was unclear. In a new study in the American Journal of Physiology–Endocrinology and Metabolism, researchers report that inflammation is the cause for the increased diabetes risk in women with PCOS.
E-Cigarette Vapor—Even when Nicotine-Free—Found to Damage Lung Cells
Released May 26, 2015 - With the use of e-cigarettes on the rise, especially among young people, research to uncover the health effects of e-cigs is becoming increasingly important. In a new study published ahead of print in AJP-Lung, researchers find that e-cig solution and vapors—even those that are nicotine-free—damage lung health.
A New Use for Statins: Asthma
Released May 26, 2015 - Researchers report that statins inhaled as a spray can treat symptoms of asthma. The findings support that statins should be explored as a new class of inhaler therapy for asthma.
APS Awards $446,000 to Its 2015 Undergraduate Research Fellows
Released May 20, 2015 - APS awards $446,000 to its 2015 undergraduate research fellows to spend an average of 10 weeks in the laboratory of an established scientist and APS member.
The Burmese Python in Wonderland: How the Snake Grows and Shrinks after It Eats
Released May 18, 2015 - The Burmese python's body and organs grow dramatically after it eats and then shrink after the meal is digested. This study is the first to link the extreme body changes directly to changes in gene expression and show how quickly gene expression shifts after the snake eats.
Cuban and American Physiological Societies Sign Historic Agreement for Research Collaboration
Released May 14, 2015 - Leadership of the APS and the Cuban Society of Physiological Science met in Havana to sign an agreement for the exchange of scientific information and resources between the two organizations. This partnership fits as part of APS’s goal of sharing breaking physiological research and will also facilitate more global interactions among Cuban, American and other international physiologists.
Fish Oil May Help with Diabetic Neuropathy
Released May 6, 2015 - New study reports that omega-3 fatty acids found in fish oil can slow or reverse nerve damage from diabetes.
Researchers Find Clues that May Predict Recovery Outcomes Following Total Hip Replacement
Released May 4, 2015 - A cross-institutional team of researchers have identified a signaling substance (MuIS) that may predict patients who will have poor muscle regeneration outcomes following hip surgery. Testing patients for the presence of MuIS before surgery may help clinicians better plan for those who will need more intensive rehab post-surgery. This manuscript was chosen as an APSselect article for May.
New Hope for Short Bowel Syndrome
Released May 4, 2015 - Researchers at Children’s Hospital Los Angeles have successfully made a small intestine that has the structural and molecular components of a healthy intestine. This article was chosen as an APSselect article for May.
Strength vs. Endurance: Does Exercise Type Matter in the Fight Against Obesity?
Released April 23, 2015 - Researchers look at which form of exercise—strength, endurance or a combination of both—work best in tandem with diet to reduce weight and change body composition among obese study participants. Results are published in the Journal of Applied Physiology.
Making the Heart Beat with Ultrasonic Waves
Released April 23, 2015 - Researchers from Drexel University demonstrate that ultrasound can increase the rate at which heart cells beat and describe the settings that can do so most effectively.
Caloric Restriction: A Fountain of Youth for Aging Muscles?
Released April 22, 2015 - Caloric restriction has been studied as a way to increase longevity in animals. Now, researchers explore how it may positively affect muscle and find that aging muscles receive the most benefit.
Tumors Prefer the Easy Way Out
Released April 16, 2015 - Researchers from Cornell University describe a new way cancer cells invade other parts of the body, identifying a new treatment target that may be more effective than current drugs.This article was chosen as an APSselect article for April.
On the Edge of Extinction: Tiny Pupfish Go without Breathing to Survive their Harsh Environment
Released March 31, 2015 - The endangered desert pupfish has made itself at home in the harsh, hot environment of Death Valley hot springs by using a surprising evolutionary adaptation: They can go for up to five hours without oxygen. Research will be presented at the 2015 Experimental Biology Meeting in Boston on Tuesday, March 31.
Diet Rich in Methionine—Found Most Abundantly in Eggs, Fish and Meats—May Promote Memory Loss
Released March 31, 2015 - Eating mostly protein in your diet? Research suggests a diet rich in eggs, fish and meats can lead to memory loss. Research will be presented at the 2015 Experimental Biology Meeting in Boston on Tuesday, March 31.
“Ice It.” Why the Ubiquitous Advice Isn’t Healing Your Injury
Released March 30, 2015 - Does icing a serious bruise actually speed recovery time and assist in muscle repair? Researchers say no. Study results to be presented at the 2015 Experimental Biology Meeting in Boston on Monday, March 30.
Blueberries Show Promise as Treatment for Post-Traumatic Stress Disorder
Released March 30, 2015 - Roughly 8 percent of people in the US suffer from post-traumatic stress disorder (PTSD). SSRIs, such as Zoloft and Paxil, are the only currently-approved therapy for PTSD, but their effectiveness is marginal. LSU researchers have found that blueberries could be an effective treatment. Research will be presented at the 2015 Experimental Biology Meeting in Boston on Monday, March 30.
NASA Astronaut-Scientists Speak at APS History of Physiology Group Symposium
Released April 1, 2015 - Astronaut-scientists from the 1998 NASA STS-90 Neurolab space mission will discuss what they learned about how the brain and nervous system work without gravity.
Why Gastrointestinal Disorders Afflict Women More Often
Released March 30, 2015 - Women are more likely to have irritable bowel syndrome and other gastrointestinal disorders than men. A new study suggests that it’s because the intestine’s nerve cells are more sluggish in women. Research will be presented at the 2015 Experimental Biology Meeting in Boston on Monday, March 30.
More Reasons Why Getting a Good Night’s Sleep Is Important
Released March 30, 2015 - Losing several hours of sleep can slow the body’s metabolism, but what about losing only a few hours? A new study finds that metabolic effects are seen even when sleep is shortened by two hours. Research will be presented at the 2015 Experimental Biology Meeting in Boston on Monday, March 30.
Sleep Apnea During Pregnancy Is Not Good for Mother or Baby
Released March 30, 2015 - Having sleep apnea while pregnant could make the baby more prone to metabolic disease as an adult. Research will be presented at the 2015 Experimental Biology Meeting in Boston on Monday, March 30.
Nobel Laureate, Leading Experts Speak in APS President’s Symposium Series
Released March 27, 2015 - APS President David M. Pollock, PhD, has organized a dynamic President’s Symposium Series for EB 2015. Focused on the theme “Physiology: Answers to Big Questions,” experts will discuss how physiology can uncover solutions for diabetes, obesity and hypertension. The series is anchored by Nobel Laureate Robert J. Lefkowitz, PhD.
APS Announces 2015 Society Lectureship Award Winners
Released March 27, 2015 - Masashi Yanagisawa, MD, PhD, Babette B. LaMarca, PhD and Jennifer S. Pollock, PhD to be awarded prestigious APS honors at Experimental Biology 2015.
Take Your Message to the Media! Attend the APS Communications Symposium
Alan Alda Center to host interactive workshop at Experimental Biology in Boston.
Cancer Drug Encourages Both Disease Regression and Loss of Taste
Released March 2, 2015 - Researchers at the University of Michigan have identified the pathway responsible for taste changes among users of chemotherapy drugs that treat basal cell carcinoma. Manuscript was chosen as an APSselect article for March.
Older Adults: Double Your Protein to Build More Muscle
Released January 30, 2015 - University of Arkansas for Medical Sciences researchers find that older adults may need to double up on the recommended daily allowance of protein to efficiently maintain and build muscle. The article is published in the AJP—Endocrinology and Metabolism and is highlighted as part of the APSselect program.