Reproducibility in Research

Reproducibility in Research:
What are the problems? How can we fix them? What happens if we don’t?

The APS Science Policy Committee’s symposium at Experimental Biology 2015 explored scientific rigor and the issues that affect the reliability of research results.

Featured Speakers:

Shai Silberberg

Shai Silberberg
NINDS/NIH
How do we improve research methods and reporting?
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Malcolm Macleod

Malcolm Macleod
Edinburgh University
Animal models for human diseases—how can we improve translation of effects to humans?
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Richard Nakamura

Richard Nakamura
CSR
What role should peer review play assessing study design and evaluating the “scientific premise” of proposals?
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Chair and Moderator:

Carrie Northcott

Carrie Northcott
Pfizer
APS Science Policy Committee
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A lack of consistent reproducibility in some pre-clinical research has serious implications for translating those findings from bench to bedside. This is a problem that requires urgent corrective action. Restoring confidence in the rigor of pre-clinical biomedical research will require all stakeholders to be a part of the solution, including basic scientists, academic institutions, industry, and publishers. NIH is committed to increasing the rigor and reliability of pre-clinical research, but funding agencies alone cannot address all the elements of the problem. Restoring confidence in pre-clinical biomedical research will require all stake-holders to be a part of the solution, including basic scientists, academic institutions, industry, and publishers. Improving reproducibility will require us to be involved, proactive, and willing to think and act differently.


 
 
  Journal Club Activity More Reproducibility Resources
 
 
 
Resources

Interviews

Interviews with the speakers and chair of the Science Policy Committee’s symposium at EB 2015 on rigor and reproducibility of research results.

Slides

Downloadable PowerPoint slides from the speakers of the Science Policy Committee's symposium on reproducibility in research.

Audio Slides Syncs

Full presentation audio synced to the talk slides

Twitter Highlights

A Storify aggregation of the APS Reproducibility Symposium tweets.

Interview: Introduction to Reproducibility Symposium

Carrie Northcott explains why the APS’s Science Policy Committee decided to tackle the topic of reproducibility at Experimental Biology 2015.

Interview: How do we improve research methods and reporting?

Shai Silberberg outlines some sources of the reproducibility problem.

Interview: Animal models for human diseases—how can we improve translation of effects to humans?

Malcolm Macleod explains flaws in some disease models and how to correct them.

Interview: What role should peer review play assessing study design and evaluating the “scientific premise” of proposals?

Richard Nakamura discusses how NIH plans to address reproducibility through changes to peer review.

MP4: “How do we improve research methods and reporting”

Audio synced to slides of Shai Silberberg’s talk.

MP4: “Animal models for human diseases—how can we improve translation of effects to humans?”

Audio synced to slides of Malcolm Macleod’s talk.

MP4: “What role should peer review play assessing study design and evaluating the ‘scientific premise’ of proposals?”

Audio synced to slides of Richard Nakamura's talk.

SLIDES: How Do We Improve Research Methods and Reporting?

Shai Silberberg's PowerPoint slides from his talk “How do we improve research methods and reporting?”

SLIDES: Animal Models for Human Diseases—How Can We Improve Translation of Effects to Humans?

PowerPoint slides for Malcolm Macleod‘s presentation, titled “Animal models for human diseases—how can we improve translation of effects to humans?”

SLIDES: Role of Peer Review in Solving the Problem of Reproducibility

Richard Nakamura’s PowerPoint slides for the Symposium. His talk is titled “What role should peer review play assessing study design and evaluating the ‘scientific premise’ of proposals?”

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