Original Classic Papers

Listed below are the articles which have been singled out as APS Classic Papers. These articles have been made free for viewing by all users.

American Journal of Physiology

Ahlquist RP. A study of adrenotropic receptors. Am J Physiol 153: 586-600, 1948.

Berne RM. Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. Am J Physiol 204: 317-322, 1963.

Cannon WB. The emergency function of the adrenal medulla in pain and the major emotions. Am J Physiol 33: 356-372, 1914.

Cannon WB. Studies on the conditions of activity in endocrine glands. V. The isolated heart as an indicator of adrenal secretion induced by pain, asphyxia and excitement. Am J Physiol 50: 399-432, 1919.

Cannon WB and de la Paz D. Emotional stimulation of adrenal secretion. Am J Physiol 28: 64-70, 1911.

Comroe JH Jr. The location and function of the chemoreceptors of the aorta. Am J Physiol 127: 176-191, 1939.

Critchlow V, Liebelt RA, Bar-Sela M, Mountcastle W, and Lipscomb HS. Sex difference in resting pituitary-adrenal function in the rat. Am J Physiol 205: 807–815, 1963.

Cross RJ and Taggart JV. Renal tubular transport: accumulation of p-aminohippurate by rabbit kidney slices. Am J Physiol 161: 181–190, 1950.

Duarte CG, Chomety F, and Giebisch G. Effect of amiloride, ouabain, and furosemide on distal tubular functiion in the rat. Am J Physiol 221: 632-639, 1971.

Falk, G. Maturation of renal function in infant rats. Am J Physiol 181: 157-170, 1955.

Fitts RH, Booth FW, Winder WW, Holloszy JO. Skeletal muscle respiratory capacity, endurance, and glycogen utilization. Am J Physiol 228: 1029–1033, 1975.

Fenn WO, Rahn H, and Otis AB. A theoretical study of the composition of the alveolar air at altitude. Am J Physiol 146: 637-653, 1946.

Fevold HL, Hisaw FL, Leonard SL. The gonad stimulating and the luteinizing hormones of the anterior lobe of the hypophysis. Am J Physiol 97: 291-301, 1931.

Fowler WS. Lung function studies. II. The respiratory dead space. Am J Physiol 154: 405-416, 1948.

Gottschalk CW, Lassiter WE, Mylle M, Ullrich KJ, Schmidt-Nielsen B, O'Dell R, and Pehling G. Micropuncture study of composition of loop of Henle fluid in desert rodents. Am J Physiol 204: 532-535, 1963.

Gottschalk CW and Mylle M. Micropuncture study of the mammalian urinary concentrating mechanism: evidence for the countercurrent hypothesis. Am J Physiol 196: 927-936, 1959.

Guyton AC, Lindsey AW, and Kaufmann BN. Effect of mean circulatory filling pressure and other peripheral circulatory factors on cardiac output. Am J Physiol 180: 463-468, 1955.

Hammel HT, Hardy JD, and Fusco MM. Thermoregulatory responses to hypothalamic cooling in unanesthetized dogs. Am J Physiol 198: 481-486, 1960.

Hellstrom B and Hammel HT. Some characteristics of temperature regulation in the unanesthetized dog. Am J Physiol 213: 547-556, 1967.

Houssay BA and Lewis JT. The relative importance to life of cortex and medulla of the adrenal glands. Am J Physiol 64: 512-521, 1923.

Ingle DJ. The effects of administering large amounts of cortin on the adrenal cortices of normal and hypophysectomized rats. Am J Physiol 124: 369–371, 1938

Ingraham RC and Visscher MB. Further studies on intestinal absorption with the performance of osmotic work. Am J Physiol 121: 771-785, 1938.

Jolliffe N, Shannon JA, and Smith HW. The excretion of urine in the dog. III. The use of non-metabolized sugars in the measurement of the glomerular filtrate. Am J Physiol 100: 301-312, 1932.

Kety SS, and Schmidt CF. The determination of cerebral blood flow in man by the use of nitrous oxide in low concentrations. Am J Physiol 143: 53-66, 1945.

Landis EM. The capillary pressure in frog mesentery as determined by micro-injection methods. Am J Physiol 75: 548-570, 1926.

Landis EM. Micro-injection studies of capillary permeability. II. The relation between capillary pressure and the rate at which fluid passes through the walls of single capillaries. Am J Physiol 82: 217-238, 1927.

Malnic G, Klose RM, and Giebisch G. Micropuncture study of renal potassium excretion in the rat. Am J Physiol 206: 674-686, 1964.

Malnic G, Klose RM, and Giebisch G. Micropuncture study of distal tubular potassium and sodium transport in rat nephron. Am J Physiol 211: 529-547, 1966.

Malnic G, Klose RM, and Giebisch G. Microperfusion study of distal tubular potassium and sodium transfer in rat kidney. Am J Physiol 211: 548-559, 1966.

Malnic G, Mello Aires M, and Giebisch G. Potassium transport across renal distal tubules during acid-base disturbances. Am J Physiol 221: 1192-1208, 1971.

Margaria R, Edwards HT, and Dill DB. The possible mechanisms of contracting and paying the oxygen debt and the role of lactic acid in muscular contraction. Am J Physiol 106: 689–715, 1933.

Marine D and Baumann EJ. Duration of life after suprarenalectomy in cats and attempts to prolong it by injections of solutions containing sodium salts, glucose and glycerol. Am J Physiology 81: 86-100, 1927.

McGregor DD, Smirk FH. Vascular responses to 5-hydroxytryptamine in genetic and renal hypertensive rats. Am J Physiol 219: 687–690, 1970.

Motley, HL, Cournand, A, Werko, L, Himmelstein, A, Dresdale, D. The influence of short periods of induced acute anoxia upon pulmonary artery pressures in man. Am J Physiol 150: 315-320, 1947.

Neely JR, Liebermeister H, Battersby EJ, and Morgan HE. Effect of pressure development on oxygen consumption by isolated rat heart. Am J Physiol 212: 804–814, 1967.

Pappenheimer JR and Soto-Rivera A. Effective osmotic pressure of the plasma proteins and other quantities associated with the capillary circulation in the hind limbs of cats and dogs. Am J Physiol 152: 471-491, 1948

Pappenheimer JR, Renkin EM and Borrero LM. Filtration, diffusion and molecular sieving through peripheral capillary membranes: A contribution to the pore theory of capillary permeability. Am J Physiol 167: 13-46, 1951.

Pitts RF and Alexander, RS. The nature of the renal tubular mechanism for acidifying the urine. Am J Physiol 144: 239-254, 1945.

Pitts RF and Lotspeich WD. Bicarbonate and the renal regulation of acid base balance. Am J Physiol 147:138-154, 1946.

Rahn H. A concept of mean alveolar air and the ventilation-bloodflow relationships during pulmonary gas exchange. Am J Physiol 158: 21-30, 1949.

Richards AN and Walker AM. Methods of collecting fluid from known regions of the renal tubules of Amphibia and of perfusing the lumen of a single tubule. Am J Physiol 118: 111-120, 1936.

Riddle O, Bates RW, and Dykshorn SW. The preparation, identification and assay of prolactin—a hormone of the anterior pituitary. Am J Physiol 105: 191-216, 1933.

Sarnoff SJ, Braunwald E, Welch GH Jr, Case RB, Stainsby WN, and Macruz R. Hemodynamic determinants of oxygen consumption of the heart with special reference to the tension-time index. Am J Physiol 192: 148–156, 1957.

Schmidt-Nielsen B. Renal tubular excretion of urea in kangaroo rats. Am J Physiol 170: 45–56, 1952.

Schmidt-Nielsen B. Urea excretion in white rats and kangaroo rats as influenced by excitement and by diet. Am J Physiol 181: 131–139, 1955.

Schmidt-Nielsen B, Osaki H, Murdaugh HV Jr, and O'Dell R. Renal regulation of urea excretion in sheep. Am J Physiol 194: 221–228, 1958.

Shannon JA. The excretion of inulin by the dog. Am J Physiol 112: 405-413, 1935.

Shannon JA and Fisher S. The renal tubular reabsorption of glucose in the normal dog. Am J Physiol 122: 765-774, 1938.

Shannon JA, Farber S, and Troast L. The measurement of glucose Tm in the normal dog. Am J Physiol 133: 752-761, 1941.

Swingle WW and Pfiffner JJ. Studies on the adrenal cortex. I. The effect of a lipid fraction upon the life-span of adrenalectomized cats. Am J Physiol 96: 153-163, 1931.

Truniger B and Schmidt-Nielsen B. Intrarenal distribution of urea and related compounds: effect of nitrogen intake. Am J Physiol 207: 971–978, 1964.

Ullrich KJ, Schmidt-Nielsen B, O'Dell R, Pehling G, Gottschalk CW, Lassiter WE, and Mylle M. Micropuncture study of composition of proximal and distal tubular fluid in rat kidney. Am J Physiol 204: 527-531, 1963.

Visscher MB, Fetcher ES Jr, Carr CW, Gregor HP, Bushey MS, and Barker DE. Isotopic tracer studies on the movement of water and ions between intestinal lumen and blood. Am J Physiol 142: 550-575, 1944.

Walker AM, Bott PA, Oliver J, and MacDowell MC. The collection and analysis of fluid from single nephrons of the mammalian kidney. Am J Physiol 134: 580-595, 1941.

Walker AM and Hudson CL. The reabsorption of glucose from the renal tubule in Amphibia and the action of phlorhizin upon it. Am J Physiol 118: 130-143, 1936.

Walker AM and Oliver J. Methods for the collection of fluid from single glomeruli and tubules of the mammalian kidney. Am J Physiol 134: 562-579, 19414.

Wall JS, Steele R, de Bodo RC, and Altszuler N. Effect of insulin on utilization and production of circulating glucose. Am J Physiol 189: 43–50, 1957.

Wearn JT and Richards AN. Observations on the composition of glomerular urine, with particular reference to the problem of reabsorption in the renal tubules. Am J Physiol 71: 209-227, 1924.

Wright FS, Strieder N, Fowler N, and Giebisch G. Potassium secretion by distal tubule after potassium adaptation. Am J Physiol 221: 437-448, 1971.

American Journal of Physiology - Cell Physiology

Fabiato A. Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am J Physiol Cell Physiol 245: C1-C14, 1983.

Kwan CY, Takemura H, Obie JF, Thastrup O, and Putney JW Jr. Effects of MeCh, thapsigargin, and La3+ on plasmalemmal and intracellular Ca2+ transport in lacrimal acinar cells. Am J Physiol Cell Physiol 258: C1006–C1015, 1990.

American Journal of Physiology - Endocrinology and Metabolism

De Léan A, Munson PJ, and Rodbard D. Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol Endocrinol Metab Gastrointest Physiol 235: E97–E102, 1978.

Merriam GR and Wachter KW. Algorithms for the study of episodic hormone secretion. Am J Physiol Endocrinol Metab 243: E310–E318, 1982.

American Journal of Physiology - Gastrointestinal and Liver Physiology

DeFronzo RA, Tobin JD, and Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol Endocrinol Metab Gastroinstest Physiol 6: E214–E223, 1979.

Journal of Applied Physiology

Gollnick PD, Armstrong RB, Saubert CW IV, Piehl K, and Saltin B. Enzyme activity and fiber composition in skeletal muscle of untrained and trained men. J Appl Physiol 33: 312-319, 1972.

Gollnick PD, Armstrong RB, Saltin B, Saubert CW IV, Sembrowich WL, and Shepherd RE. Effect of training on enzyme activity and fiber composition of human skeletal muscle. J Appl Physiol 34: 107-111, 1973.

Hammel HT, Jackson DC, Stolwijk JAJ, Hardy JD, and Strømme SB. Temperature regulation by hypothalamic proportional control with an adjustable set point. J Appl Physiol 18: 1146-1154, 1963.

Howell JBL, Permutt S, Proctor DF, and Riley RL. Effect of inflation of the lung on different parts of pulmonary vascular bed. J Appl Physiol 16: 71-76, 1961.

Murdaugh HV Jr, Schmidt-Nielsen B, Doyle EM, and O'Dell R. Renal tubular regulation of urea excretion in man. J Appl Physiol 13: 263–268, 1958.

Permutt S, Howell JBL, Proctor DF, and Riley RL. Effect of lung inflation on static pressure-volume characteristics of pulmonary vessels. J Appl Physiol 16: 64-70, 1961.

Riley RL and Cournand A. "Ideal" alveolar air and the analysis of ventilation-perfusion relationships in the lungs. J Appl Physiol 1: 825-847, 1949.

Riley RL and Cournand A. Analysis of factors affecting partial pressures of oxygen and carbon dioxide in gas and blood of lungs: theory. J Appl Physiol 4: 77-101, 1951.

Severinghaus, JW, and Bradley, AF. Electrodes for blood Po2 and Pco2 determination. J Appl Physiol 13: 515-520, 1958.

Journal of Neurophysiology

Bessou P and Perl ER. Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J Neurophysiol 32: 1025–1043, 1969.

Christensen BN and Perl ER. Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn. J Neurophysiol 33: 293–307, 1970.

Dowling JE and Werblin FS. Organization of retina of the mudpuppy, Necturus maculosus. I. Synaptic structure. J Neurophysiol 32: 315–338, 1969.

Fernandez C and Goldberg JM. Physiology of peripheral neurons innervating otolith organs of the squirrel monkey. I. Response to static tilts and to long-duration centrifugal force. J Neurophysiol 39: 970–984, 1976.

Fernandez C and Goldberg JM. Physiology of peripheral neurons innervating otolith organs of the squirrel monkey. II. Directional selectivity and force-response relations. J Neurophysiol 39: 985–995, 1976.

Fernandez C and Goldberg JM. Physiology of peripheral neurons innervating otolith organs of the squirrel monkey. III. Response dynamics. J Neurophysiol 39: 996–1008, 1976.

Funahashi S, Bruce CJ, and Goldman-Rakic PS. Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. J Neurophysiol 61: 331–349, 1989.

Goldberg JM and Brown PB. Response of binaural neurons of dog superior olivary complex to dichotic tonal stimuli: some physiological mechanisms of sound localization. J Neurophysiol 32: 613–636, 1969.

Grafstein B. Mechanism of spreading cortical depression. J Neurophysiol 19: 154–171, 1956.

Henneman E, Somjen G, and Carpenter DO. Functional significance of cell size in spinal motoneurons. J Neurophysiol 28: 560–580, 1965.

Henneman E and Olson CB. Relations between structure and function in the design of skeletal muscles. J Neurophysiol 28: 581–598, 1965.

Henneman E, Somjen G, and Carpenter DO. Excitability and inhibitability of motoneurons of different sizes. J Neurophysiol 28: 599–620, 1965.

Kravitz EA, Kuffler SW, and Potter DD. Gamma-aminobutyric acid and other blocking compounds in Crustacea. III. Their relative concentrations in separated motor and inhibitory axons. J Neurophysiol 26: 739–751, 1963.

Kuffler SW. Discharge patterns and functional organization of mammalian retina. J Neurophysiol 16: 37–68, 1953.

Leão AAP. Spreading depression of activity in the cerebral cortex. J Neurophysiol 7: 359–390, 1944.

Leão AAP. Pial circulation and spreading depression of activity in the cerebral cortex. J Neurophysiol 7: 391–396, 1944.

Leão AAP. Further observations on the spreading depression of activity in the cerebral cortex. J Neurophysiol 10: 409–414, 1947.

Marmarelis PZ and Naka K-I. Nonlinear analysis and synthesis of receptive-field responses in the catfish retina. II. One-input white-noise analysis. J Neurophysiol 36: 619–633, 1973.

McPhedran AM, Wuerker RB, and Henneman E. Properties of motor units in a homogeneous red muscle (soleus) of the cat. J Neurophysiol 28: 71–84, 1965.

Naka K-I and Nye PW. Role of horizontal cells in organization of the catfish retinal receptive field. J Neurophysiol 34:785–801, 1971.

Naka K-I, Marmarelis PZ, and Chan RY. Morphological and functional identifications of catfish retinal neurons. III. Functional identification. J Neurophysiol 38: 92–131, 1975.

Otsuka M, Kravitz EA, and Potter DD. Physiological and chemical architecture of a lobster ganglion with particular reference to gamma-aminobutyrate and glutamate. J Neurophysiol 30: 725–752, 1967.

Rall W. Distinguishing theoretical synaptic potentials computed for different soma-dendritic distributions of synaptic input. J Neurophysiol 30: 1138–1168, 1967.

Rall W, Burke RE, Smith TG, Nelson PG, and Frank K. Dendritic location of synapses and possible mechanisms for the monosynaptic EPSP in motoneurons. J Neurophysiol 30: 1169–1193, 1967.

Rall W and Shepherd GM. Theoretical reconstruction of field potentials and dendrodendritic synaptic interactions in olfactory bulb. J Neurophysiol 31: 884–915, 1968.

Segev I and Rall W. Computational study of an excitable dendritic spine. J Neurophysiol 60: 499–523, 1988.

Sperry RW. Optic nerve regeneration with return of vision in anurans. J Neurophysiol 7: 57–69, 1944.

Sperry RW. Restoration of vision after crossing of optic nerves and after contralateral transplantation of eye. J Neurophysiol 8: 15–28, 1945.

Werblin FS and Dowling JE. Organization of the retina of the mudpuppy, Necturus maculosus. II. Intracellular recording. J Neurophysiol 32: 339–355, 1969.

Wuerker RB, McPhedran AM, and Henneman E. Properties of motor units in a heterogeneous pale muscle (m. gastrocnemius) of the cat. J Neurophysiol 28: 85–99, 1965.

Wurtz RH. Visual receptive fields of striate cortex neurons in awake monkeys. J Neurophysiol 32: 727–742, 1969.

Wurtz RH. Comparison of effects of eye movements and stimulus movements on striate cortex neurons of the monkey. J Neurophysiol 32: 987–994, 1969.

Yin TCT and Chan J. Interaural time sensitivity in medial superior olive of cat. J Neurophysiol 64: 465–488, 1990.