» Essays on APS Classic Papers

The American Physiological Society is proud to announce that the full historical content of its 14 journals, going back to the very first issues of the American Journal of Physiology in 1898, is now available online. To commemorate this event, we have asked authors to write essays on some of the most significant articles from the body of APS literature.

Adrenal cortex: scalpels, syringes, and separatory funnels by Susan F. Akana

The physiology of the peripheral vestibular system: the birth of a field by Dora E. Angelaki

Comments on Classical Papers by K. M. Baldwin

The exercise dose response: key lessons from the past by Marcas M. Bamman

Postnatal Developmental Renal Physiology: A Study of Historic Significance by Michel Baum

Alpha and Beta Adrenergic Receptors: Ahlquist's Landmark Hypothesis of a Single Mediator with Two Receptors by David B. Bylund

Estimation of dose-response curves and identification of peaks in hormone pulsations: classic marriages of statistics to science by Douglas Curran-Everett

Adrenocortical function, feedback, and alphabet soup by Mary F. Dallman

The use of mammalian cortical kidney slices for the study of tubule secretion: a pioneering step toward understanding organic anion transport by William H. Dantzler

Berne’s adenosine hypothesis of coronary blood flow control by Eric O. Feigl

Acute hypoxia and pulmonary vasoconstriction in humans: uncovering the mechanism of the pressor response by Alfred P. Fishman

Two classic papers in acid-base physiology: contributions of R. F. Pitts, R. S. Alexander, and W. D. Lotspeich by Gerhard Giebisch

Discovery of the luteinizing hormone of the anterior pituitary gland by H. Maurice Goodman

Studying the visual system in awake monkeys: two classic papers by Robert H. Wurtz by Michael E. Goldberg

Roger Sperry: pioneer of neuronal specificity by Bernice Grafstein

Relating cardiac performance with oxygen consumption: historical observations continue to spawn scientific discovery by David D. Gutterman and Allen W. Cowley, Jr.

The pioneering use of systems analysis to study cardiac output regulation by John E. Hall

Ca-induced Ca release: lessons regarding cell models by David R. Harder

Synaptic chemistry in single neurons: GABA is identified as an inhibitory neurotransmitter by Ronald Harris-Warrick

The development of clearance methods for measurement of glomerular filtration and tubular reabsorption by T. H. Hostetter and T.W. Meyer

Nature vs. nurture: can exercise really alter fiber type composition in human skeletal muscle? by Christopher P. Ingalls

A dogged pursuit of coincidence by Philip X. Joris

Muscle, liver, and pancreas: Three Musketeers fighting to control glycemia by Amira Klip and Mladen Vranic

Dead space: Simplicity to complexity by Robert A. Klocke

Significance of urea transport: the pioneering studies of Bodil Schmidt-Nielsen by Juha P. Kokko and Jeff M. Sands

Hypothalamic control of body temperature: insights from the past by Gary W. Mack

Placing pain on the sensory map: Classic papers by Ed Perl and colleagues by Peggy Mason

Making the retina approachable by Gary Matthews

The size principle: a rule describing the recruitment of motoneurons by Lorne M. Mendell

Microvascular permeability, ultra-filtration, and restricted diffusion by C. C. Michel

Sex-based physiology prior to political correctness by Virginia M. Miller

Stresses on pulmonary blood vessels by Wayne Mitzner

The basis for transport across epithelial cells by Marshall H. Montrose

Comroe's study of aortic chemoreceptors: a path well chosen by Judith A. Neubauer

The significance of the blood gas analyzer by Hershel Raff

Discovering the role of the adrenal gland in the control of body function by David C. Randall

Eugene M. Landis and the physiology of the microcirculation by E. M. Renkin

Discovering the mechanism of capacitative calcium entry by Juan A. Rosado

Micropuncture: unlocking the secrets of renal function by Jeff M. Sands

Experimental validation of the countercurrent model of urinary concentration by James A. Schafer

What do dendrites and their synapses tell the neuron? by Idan Segev

First electrodes for blood Po2 and Pco2 determination by John W. Severinghaus

Anterior pituitary hormones: development of a bioassay leading to the discovery of prolactin by M. Susan Smith

Aristides Leão’s discovery of cortical spreading depression by G. G. Somjen

Renal Potassium Transport: The pioneering studies of Gerhard Giebisch by Bruce A. Stanton

Dr. Bernice Grafstein’s paper on the mechanism of spreading depression by Anthony J. Strong

The paper that completely altered our thinking about cerebral blood flow measurement by Richard J. Traystman

The beginning of a fantastic, unanswered question: is 5-HT involved in systemic hypertension? by Stephanie W. Watts

Understanding pulmonary gas exchange: ventilation-perfusion relationships by John B. West

Circuits and Properties of Signal Transmission in the Retina by Paul Witkovsky, William K. Stell, and Andrew T. Ishida

Discovering spatial working memory fields in prefrontal cortex by Xiao-Jing Wang

by Hershel Raff, Dale Benos, and Margaret Reich

An introduction to the JN Classic Papers by Eve Marder.

Read the original articles that have been singled out as "APS Classic Papers" for free.

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