Thomas R. Kleyman, MD, is a Professor of Medicine, Cell Biology and Physiology, and Pharmacology, and Chief of the Renal-Electrolyte Division at the University of Pittsburgh. He received his medical degree from Washington University in St. Louis, and trained in Internal Medicine and Nephrology at Columbia-Presbyterian Medical Center in New York. His postdoctoral training in transport physiology and membrane biochemistry was at Columbia University. He previously served on the faculty of Columbia University and the faculty of University of Pennsylvania.
Dr. Kleyman served as an Associate Editor of the American Journal of Physiology: Renal Physiology before assuming the position of its Editor-in-Chief in July of 2007. He was a member of the editorial board of the Journal of Biological Chemistry, and is currently a member of the editorial board of the Journal of Clinical Investigation. Dr. Kleyman has served on several national peer review groups and is currently a member of an NIH study section. Within the American Physiological Society, he served as a member of the Joint Programming Committee and as Chair of the Epithelial Transport Group. Within the American Heart Association, Dr. Kleyman served as chair of the research committee of the Pennsylvania-Delaware Affiliate, chair of the peer review steering committee of the Mid-Atlantic consortium, member of National Research Committee, and member of the Council on the Kidney in Cardiovascular Disease. Dr. Kleyman is a member of numerous societies in addition to the APS and AHA, including the American Society for Clinical Investigation, the Association of American Physicians, and the American Society of Nephrology.
Dr. Kleyman’s research is concentrated on epithelial ion channels. Recent work has focused on studies of the structure of the epithelial sodium channel (ENaC), on identifying key sites within ENaC’s extracellular domains that modulate channel gating, on the processing of these channels within the biosynthetic pathway, and on their regulation by proteases. He is also studying the regulation of ENaCs and maxi K+ channels by mechanical forces.