Extracellular Matrix in Cardiovascular Pathophysiology

Guest Editor Dr. Luis A. Martinez-Lemus, Guest Editor Dr. Maria Bloksgaard, and Deputy Editor Dr. Merry L. Lindsey, along with the editorial team at AJP-Heart and Circulatory Physiology, invite submission of original research articles on the mechanisms associated with remodeling of the extracellular matrix (ECM) and its role in the development of cardiovascular pathologies.

The ECM is present in all cardiovascular tissues and is a major determinant of the viscoelastic characteristics of the heart and blood vessels. Consequently, ECM remodeling encompasses synthesis, degradation, and crosslinking, and has been associated with changes in the stiffness of the cardiovascular circuit. Recent reports indicate that stiffening of the heart and blood vessels is highly predictive of life-threatening cardiovascular events and occurs before the overt manifestation of other cardiovascular risk factors such as hypertension and diabetes. As cardiovascular disease (CVD) is expected to remain the main cause of death in many societies for years to come, it is of the outmost importance that research focused on the mechanisms that lead to CVD remain a priority for the scientific community. The editors welcome submissions which aid in our understanding of the mechanisms that induce ECM remodeling in cardiovascular tissues, how these mechanisms participate in the processes that lead to changes in cardiovascular function and mechanics, and how these changes eventually lead to overt cardiovascular pathologies. An additional area of interest includes novel approaches to promote amelioration of the cardiovascular stiffening associated with hypertension, and diabetes.

We welcome original research manuscripts focused on specific mechanisms that intersect ECM-cellular interactions in any area or component of the cardiovascular system, as well as on the mechanisms by which specific ECM remodeling characteristics affect cell signaling, inflammation, and tissue repair. We encourage submission of investigations using a variety of experimental approaches, including in vivo, ex vivo and in vitro studies, as well as studies on computational modeling. Authors are further encouraged to discuss the translational perspective of their basic research findings in animal models, in vitro and computational studies with emphasis on future clinical perspectives and/or possible development of clinical/pharmacotherapies, if applicable. All manuscripts accepted from this Call for Papers will be included in a unique online article collection to further highlight the importance of this topic.

We will consider both original research articles and review articles. For review articles only, authors should email the editorial office (khkeehan@verizon.net) a pre-submission inquiry including a working title, author and affiliation list, abstract and brief outline of the content for approval by the editors. 

All manuscripts accepted from this Call for Papers will be included in a unique online article collection to further highlight the importance of this topic. The article collection will also include specially commissioned Review articles on the topic.

All manuscripts should be submitted online at http://ajpheart.msubmit.net/cgi-bin/main.plex

During the online submission process, under the "Keywords & Special Sections" tab, please use the "Category" drop-down menu and select “Call for Papers: Extracellular matrix in cardiovascular pathophysiology"

Manuscripts will undergo normal peer review as they are received. Accepted manuscripts will be published online as they are accepted. Articles published from this Call for Papers will be highlighted with a special “Call for Papers” banner on the article PDF, as well as included in the “Call for Papers: Role of the extracellular matrix in cardiovascular pathophysiology” online article collection at time of publication.

Manuscripts must be submitted by February 1, 2018 to be eligible for inclusion in this Call for Papers. If you have any questions please contact Kara Hansell Keehan, Executive Editor, via email at khkeehan@verizon.net.