Systems Biology in Gastrointestinal Physiology and Diseases
A system is defined as a set of interacting components forming an integrated whole. The ability to generate genome-wide measurements on a system is arguably the single greatest force driving the rise of the systems biology field. Furthermore, in comparison to the classical hypothesis-driven approach, a systems biology approach is an unbiased data-driven strategy, where “omics” data integration reveals the central regulators (hubs) that control disease pathogenesis. Systems biology studies related to the characterization and the integration of different omes (genome, transcriptome, epigenome, proteome, metabolome, microbiome) into molecular networks, aiming to identify central regulators (hubs) of gastrointestinal functions and disease initiation and progression and to develop novel therapeutics targeting these network hubs, are of great interest to readers of the American Journal of Physiology-Gastrointestinal and Liver Physiology.