Mechanisms of Host and Microbiome Interactions

The gut microbiome is an “organ” of the digestive tract that is highly individual, easily changed by host, dietary and environmental factors, and hugely impacting to health and disease.  Its relationships to the host is complex, dynamic and bidirectional. In health, the gut microbiome is essential not only for intestinal homeostasis, but also for extra-intestinal interactions with other organ systems, immune and metabolic networks, and growth and development. In disease, intestinal dysbiosis can be the cause, trigger, and/or contributor to the pathophysiology of disorders.  Mechanistic studies of host and microbiome interactions, and review articles of the current state of knowledge, the unmet needs, challenges, and opportunities in this area would therefore be timely and of great interest to readers of the American Journal of Physiology-Gastrointestinal and Liver Physiology. Deadline: 12/1/17.