Immune Mechanisms of Gastrointestinal Cancer

As complex physiologic systems, cancers develop mechanisms preventing the normal immune system from attacking and attenuating the promotion of gastrointestinal and other cancers. The field of cancer immunology is rapidly advancing with increased knowledge of immune alterations in cancers along with cancer immunotherapies designed to retard the progression of cancer. The mechanisms involved in both promotion of the cancer immune alterations as well as how the emerging therapies act are only partially understood and still require significant advances. Progress can occur not only in discovery of pathways involved and cancer immunoregulation, but also in novel methods to study the complex interactions between cancer epithelia and participants in the cancer microenvironment including immune and inflammatory cells.  Advances can occur in novel animal model approaches as well as in microscopic and other methods of analysis that can be used to describe the unique contributions of immune/inflammatory cells in cancer development. Considerations of the mechanisms of gastrointestinal cancer utilizing physiological principles are of great interest for readers of the American Journal of Physiology - Gastrointestinal and Liver Physiology. Deadline: 12/1/17.