Article Types

Research Articles

Research articles present important new research results including the entire contents of a research project. Research articles include an abstract, an introduction, methods and results sections, a discussion, and relevant citations. Large data sets are welcome for inclusion in the online publication. Articles are peer-reviewed.


This category of article serves as a forum in which to disseminate new and original lines of thinking in physiology. These short articles go beyond the scope of invited reviews and should present original ideas that can be derived from our current knowledge base. Some Perspectives articles may challenge current dogma and will be considered for publication based on the scientific merit of the argument presented. These Perspective articles will be subject to peer review. Some articles will be invited, but unsolicited articles are welcome. These articles should be about 1,500 words long, excluding references, and may include two figures.

Innovative Methodology

Research in physiology depends crucially on the development of new methods of data collection and analysis. Manuscripts submitted under this category should describe new methods for the recording, collection, and/or analysis of data relevant to understanding how the physiological system works. Manuscripts will be reviewed taking into consideration the following criteria:

  • The novelty of the new method. Papers should not be minor incremental improvements of old methods, but have a real new component.
  • The manuscript must describe the method in sufficient detail to enable others to implement or replicate the method or procedure.
  • The manuscript should carefully describe the advantages and disadvantages of the new method, with its limitations and strengths laid out clearly for the reader.
  • The manuscript must illustrate the use of the method to demonstrate that it actually works. It is not necessary to use the method in an extensive study of a biological problem, but a "proof of principle" demonstration is required. Where possible, the method should be applied to real physiological data.
  • Manuscripts should be of the length required to meet these criteria. Extensive technical details, mathematical derivations, etc. can be placed into an Appendix if they will interrupt the flow of the manuscript but may be additionally helpful to others wishing to implement the technique.

Review Articles

Review articles provide synthesis of state-of-the-art knowledge in a defined area highlighting new questions and pointing to future research directions. They encompass examination of biological processes, systems, and models, and technologies for their study. The primary purpose is to educate readers by providing a comprehensive view of completed works presented in a concise, unified format; however, appropriate inclusion of unpublished data is permissible. Utilization of figures is encouraged. Typically, reviews are invited and all are peer-reviewed.

Please note that prior to review, all review articles will be examined for originality using CrossCheck screening software to compare the submitted text to all available literature, including previous publications from the same author(s).


Editorials provide commentary by the Editor, Associate Editors, and other scientists and experts on issues related to the Journal's mission as well as of general interest to our readers. Unsolicited editorials will be considered for publication. Acceptance will reside with the editors.

Editorial Focus

Editorial Focus articles are commentaries on papers of unusual interest published in the journal that were chosen by the Editor to be highlighted by a brief Editorial Focus commentary. They should describe the most important conclusions of the paper; place the paper into context with the current state-of-the-art; highlight controversial issues; when relevant, denote strengths and weaknesses of the paper; and review questions that remain to be addressed.

Letters to the Editor

In all cases, determining whether a proposed Letter to the Editor is acceptable for publication is a matter committed to the discretion of the editors. Letters, including an informative title, should be short, approximately one journal column (500 words). Letters are reviewed by the appropriate editor and are subject to editing and possible abridgment. Letters to the Editor must be authored by experts in the field under discussion, such expertise having been demonstrated by original research published by the author(s) in peer-reviewed journals indexed in the major services, such as PubMed. Letters to the Editor should not include original, unpublished data. If a proposed Letter is found acceptable, a copy will be sent to the author of the original article if applicable; that author will have an opportunity to provide a rebuttal with new material that will be considered for publication with the Letter. Letters to the Editor may also simply address matters of general interest to the readership.


AJP - GI publishes a series of invited "Themes" articles on specific topics, which are concise Perspectives covering scientific areas of new discoveries, rapid progress, and exciting new opportunities in the field of gastrointestinal, hepatobiliary, and pancreatic research. For a list of current and past Themes articles, click here.


Various article types can be published under the following Categories, or headings:

  • Mucosal Biology
  • Inflammation/Immunity/Mediators
  • Hormones and Signaling
  • Neuroregulation and Motility
  • Liver and Biliary Tract
  • Pancreas
  • Cancer Biology

Calls for Papers

Calls for Papers will have headings that change depending on the topic. Manuscripts of any type may be submitted in response to an announced Call for Papers. These manuscripts are peer reviewed, and are published together under the topic heading.

Special Sections

Manuscripts of any type may be submitted to one of these Special Sections.

Translational Physiology

The field of Translational Physiology is an area of research that bridges the gap between basic physiology and patient care. Original papers in this field may transfer clinical insights into hypotheses that can be tested and validated in the basic research laboratory, or they may transfer knowledge gained from basic research to human physiology or even to improved methods of treating or preventing disease.

Historical Articles

Manuscripts on the history of physiology may be submitted to the Editor.