The American Journal of Physiology - Endocrinology and Metabolism publishes original, mechanistic studies on the physiology of endocrine and metabolic systems. Molecular, subcellular, and cellular studies in whole animals or humans will be considered. Specific themes include, but are not limited to, mechanisms of hormone and growth factor action; regulation of metabolism and energy balance; integrative organ cross talk; paracrine and autocrine control of endocrine cell performance; function and activation of hormone receptors; endocrine or metabolic control of channels, transporters and membrane function; differentiation of endocrine and reproductive cell function; temporal analysis of hormone secretion and metabolism; and mathematical/kinetic modeling and analysis of hormone action or metabolism. Novel molecular, immunological, or biophysical studies of hormone action are also welcome.