Special Instructions for Physiology in Medicine

Manuscripts submitted for the Physiology in Medicine series should discuss a relatively narrow aspect of basic physiology as it relates to the pathophysiology or treatment of a specific disease (or group of diseases). The disease in question should be one that the specialist in internal medicine commonly encounters in his/her practice. By emphasizing a strong connection between laboratory research and clinical medicine, we hope to stimulate interest in translational research among clinicians and to encourage medical students and young physicians to follow a scientific pathway in their careers. However, authors should be aware that the PIM articles will be designed to appeal primarily to clinicians who may not be specifically trained in current laboratory methods so that descriptions of laboratory methods and physiologic processes must be accessible to an intelligent, medically trained non‐expert.

The main point of the article should be to describe how important scientific discoveries or principles have affected our understanding of a disease, with implications for diagnosis or treatment. We intend for these articles to be highly focused, usually making only a few teaching points, but doing so in a way that makes the knowledge stick in the readers’ memory. In addition to describing important aspects of laboratory research that have elucidated physiologic mechanisms, the manuscripts should also detail the ways in which this knowledge has had an impact on our understanding of the way diseases develop, are diagnosed, or treated in everyday practice.

Manuscripts for this series must be evidence based (with appropriate citations) rather than being based on expert opinion, although an expert interpretation of diverging points of view are often illuminating. We encourage the use of glossaries for explanation of terms that might be unfamiliar to the clinician. Liberal use of figures (if scientifically necessary in color) is also encouraged. We think that manuscripts in this series are often enhanced by collaboration between a bench researcher and a clinician and for this reason, we encourage joint authorship.

Manuscript length should not exceed 2500 words plus tables and figures, with no more than 70 references. Graphics should be used liberally and should avoid excessive complexity. Because the articles are meant to be informative and to engage the clinician, they should be focused but not definitive, archival reviews. Each manuscript should conclude with a paragraph that summarizes the importance of the discussion for the clinician in easily understandable language.

References should be listed and cited in the style of the journals of the American Physiological Society. Authors should refer to the Instructions for Authors appropriate for the specific APS journal to which the PIM article will be submitted.