Data Repository Standards

Unique Materials and Data Banks

Work published in the APS Journals must necessarily be independently verifiable. Authors describing results derived from unique materials, for example: antibodies, recombinant plasmids and cloned DNAs, and mutant cell lines or viruses, are expected to make such materials available to qualified investigators on request. In addition, authors are encouraged to make data that underlie the conclusions reported in the article freely available via public repositories or available to readers upon request. 

Data Repositories

Authors should submit complete data sets to the appropriate public databases prior to manuscript submission.  If the data sets are a private resource, authors should provide login credentials (username and password) that will allow referees access during review., Information for accessing the data sets should be included in the article's Materials and Methods section.

 Mandatory deposition  Suitable repositories
 Protein sequences  Uniprot

 DNA and RNA sequences  Genbank
 DNA DataBank of Japan (DBBJ)
 EMBL Nucleotide Sequence Database (ENA)

 DNA and RNA sequencing data  NCBI Trace Archive
 NCBI Sequence Read Archive (SRA)

 Microarray data (must be MIAME compliant)  Gene Expression Omnibus (GEO)

 RNA-Seq and Chip-seq  Gene Expression Omnibus (GEO)

A comprehensive list of data repositories can be found here;

Links to Data from Article (non-peer-reviewed)

Along with the submitted manuscript, one author, preferably the corresponding author, may provide a working URL from their institutional website that links to additional datasets and/or detailed methods and protocols, and that may be updated from time to time. Only one URL may be provided, taking the reader to a top level screen should materials reside on multiple levels. Materials accessible through this link a) will not be considered part of the manuscript; b) will not be peer reviewed; and c) should not be submitted with the manuscript. This facility is provided by the APS in cases where authors consider that additional materials could be useful to readers seeking to replicate or expand upon the work. However, the Journal Editors and the APS take no responsibility for materials posted and linked to in this way. The declaration in the manuscript pointing to these materials will be included as an ‘endnote’ (following all text and preceding the references in the manuscript) in the following format:

At the request of the author(s), readers are herein alerted to the fact that additional materials related to this manuscript may be found at the institutional website of one of the authors, which at the time of publication they indicate is: [Insert URL here]. These materials are not a part of this manuscript, and have not undergone peer review by the American Physiological Society (APS). APS and the journal editors take no responsibility for these materials, for the website address, or for any links to or from it.