This book brings together current research on the way in which blood flow can regulate vascular function with particular emphasis on vascular tone. Evidence that this occurs is derived from the study of isolated cellular and tissue systems, in vitro vascular segments and vascular beds from both animals and humans. Considerable attention is devoted in this book to the role of the endothelium. The book also examines the cellular and sub-cellular mechanisms involved; the effective stimulus; the signal transduction systems; the role of flow-dependent mechanisms in various physiological regulating processes; and the role of flow in the long-term design of the circulation system.
Edited by John A. Bevan, Gabor Kaley, and Gabor M. Rubanyi
1995, 384 pp.; 90 illus., ISBN 019-507842-X