APS Member Access to Monograph Series Books

The APS has collaborated with Springer to digitize 34 book titles previously published in the APS monograph series. Additionally, the APS and Springer will be publishing new titles. Both the  previously published and new titles in the monograph series are freely available to APS Members.

APS members should click the hyperlink labeled "Free to Members" next to each title.  If you are not a member, click "Purchase eBook" to purchase access, or join APS to start enjoying the many benefits that our 11,000 members currently enjoy.

Newest Titles

Molecular and Cellular Mechanobiology cover

Molecular and Cellular Mechanobiology

 Shu Chien, Adam J. Engler, and Peter Yingxiao Wang (Eds.)

2016, XIII + 302 pp.; 58 illus., 57 in color

ISBN 978-1-4939-5617-3 (ebook); 978-1-4939-5615-9 (hardcover)

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  • Helps physiologists and biologists interested in mechanobiology but new to the field to understand the impact of mechanobiology on physiological regulation in health and disease
  • Details the roles of mechanobiology in the pathogenesis, diagnosis, treatment and prevention of diseaseCovers basic principles in physiological conditions, as well as examples of clinical applications

This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.

Circadian Clocks cover

Comparative Physiology of the Vertebrate Kidney

Dantzler, William H.

2016, x + 292 pp.; 17 illus., 1 in color

ISBN 978-1-4939-3734-9 (ebook); 978-1-4939-3732-5 (hardcover)

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  • A completely updated and revised new edition
  • Compares and integrates renal physiology across all the major classes of vertebrates
  • Identifies gaps in our knowledge of comparative renal physiology and indicates areas of future research

This second edition, published July 2016, offers a comprehensive overview of the physiological functions of vertebrate kidneys from a comparative viewpoint, with particular emphasis on nonmammalian vertebrates. The topics covered include renal structure; glomerular ultrafiltration; tubular transport of inorganic ions, organic substances, and fluid; and urine dilution and concentration. Mammalian renal function is only considered for purposes of comparison with nonmammalian renal function and as a frame of reference for some of the discussions. The major findings on nonmammalian renal function and the important unanswered questions raised by those findings are described in detail. As such, the book provides comprehensive information on comparative renal function for biological scientists and advanced students of biology with some knowledge of physiology and a desire to know more about renal function in vertebrates, and for mammalian renal physiologists who wish to obtain a broader view of renal function.

Circadian Clocks cover

Circadian Clocks: Role in Health and Disease

Gumz, Michelle L. (Ed.)

2016, vi + 378 pp.; 43 illus., 22 in color

ISBN 978-1-4939-3450-8 (ebook); 978-1-4939-3448-5 (hardcover)

Series: Physiology in Health and Disease

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  • Updates readers on new findings concerning the essential role of biological rhythms
  • Addresses both basic research and clinical aspects
  • Written by leading scientists and clinicians

This book sheds new light on the molecular mechanisms that generate circadian rhythms. It examines how biological rhythms influence physiological processes such as sleep, hormone synthesis and secretion, immunity, kidney function, the cardiovascular system, blood pressure, and the digestive system. Clinical implications are considered while exploring the impact of rhythms on neuropsychiatric disorders and chronotherapy’s potential for reducing cardiovascular risk. Offering a cross-section of expertise in both basic and translational (bench-to-bedside) research, this book serves as a guide for physicians and scientists who wish to learn more about the impact of circadian rhythms on physiological processes in health and disease.

Ion Channels cover

Ion Channels and Transporters of Epithelia in Health and Disease

Hamilton, Kirk L., Devor, Daniel C. (Eds.)

2016, xiv + 1019 pp.; 137 illus., 44 in color

ISBN 978-1-4939-3366-2 (ebook); 978-1-4939-3364-8 (hardcover)

Series: Physiology in Health and Disease

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  • Updates readers on essential findings concerning the cell physiology, biochemistry, pathophysiology and pharmacology of epithelial ion transport
  • Addresses both basic research and clinical aspects
  • All chapters written by leading scientists and clinicians

This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels.

Sodium and Water Homeostasis cover

Sodium and Water Homeostasis

Comparative, Evolutionary and Genetic Models

Hyndman, Kelly Anne, Pannabecker, Thomas L. (Eds.)

2015, VI + 325 pp.; 25 illus., 40 in color.

ISBN 978-1-4939-3213-9 (ebook); 978-1-4939-3212-2 (hardcover)

Series: Physiology in Health and Disease

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  • Features current innovative topics in the field of sodium and water homeostasis
  • Features domestic and international contributions from experts in the field
  • Covers multiple organ systems and cellular processes

This book presents cutting edge methods that provide insights into the pathways by which salt and water traverse cell membranes and flow in an orchestrated fashion amongst the many compartments of the body. It focuses on a number of molecular, cellular and whole animal studies that involve multiple physiological systems and shows how the internal milieu is regulated by multifactorial gene regulation, molecular signaling, and cell and organ architecture.

Topics covered include: water channels, the urinary concentrating mechanism, angiotensin, the endothelin system, miRNAs and MicroRNA in osmoregulation, desertadapted mammals, the giraffe kidney, mosquito Malpighian tubules, and circadian rhythms. The book highlights how different approaches to explaining the same physiological processes greatly increase our understanding of these fundamental processes. Greater integration of comparative, evolutionary and genetic animal models in basic science and medical science will improve our overall grasp of the mechanisms of sodium and water balance.

Marine Physiology cover

Marine Physiology Down East:

The Story of the Mt. Desert Island

Biological Laboratory

Evans, David H.

2015, XIX + 1094 pp.; 118 illus., 117 in color.

ISBN 978-1-4939-2959-7

Series: Perspectives in Physiology

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  • An exciting document for former, current and future scientists and friends of the Mount Desert Island Biological Laboratory (MDIBL)
  • Provides a scientific genealogy of the MDIBL
  • Combines research, administrative and social histories of the MDIBL

This volume offers a comprehensive history of the Mount Desert Island Biological Laboratory (MDIBL), one of the major marine laboratories in the United States and a leader in using marine organisms to study fundamental physiological concepts. Beginning with its founding as the Harpswell Laboratory of Tufts University in 1898, David H. Evans follows its evolution from a teaching facility to a research center for distinguished renal and epithelial physiologists. He also describes how it became the site of major advances in cytokinesis, regeneration, cardiac and vascular physiology, hepatic physiology, endocrinology and toxicology, as well as studies of the comparative physiology of marine organisms. Fundamental physiological concepts in the context of the discoveries made at the MDIBL are explained and the social and administrative history of this renowned facility is described.

Mechanism of Muscular Contraction cover

Mechanism of Muscular Contraction

Rall, Jack A.

2014, XIII + 471 pp.; 179 illus., 34 illus. in color.

ISBN 978-1-4939-2007-5

Series: Perspectives in Physiology

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  • Describes the evolution of muscular contraction concepts since the discovery of sliding filaments
  • Includes detailed scientific histories of principal investigators in the field
  • Features information on contraction coupling and the role of calcium in contraction and relaxation

Fundamental discoveries in the 1950s relating to the mechanism of muscle contraction fueled an explosion of knowledge in the latter half of the 20th century. This book traces in depth the evolution of ideas from the 1950s into the 21st century. In a scholarly yet highly readable monograph, the book describes the history on which our current understanding of muscle function is based. This is the most comprehensive study and first book-length treatment of the muscle field in over forty years.

In order to provide perspective into the thinking about an issue at the time of its discovery, often the investigators describe in their own words an important result or conclusion as it appeared in an original paper. Numerous figures from the original papers are included in order to allow the reader to see the data that led to important conclusions. More than a history of experimental facts, the book describes backgrounds of many of the key investigators to allow a deeper insight into their motivations and approach to science. Controversies in the muscle field are discussed along with some missed opportunities and false trails. An amazing variety of experimental techniques have been brought to bear on the investigation of the mechanism of muscular contraction. Background of these various techniques is presented in order to gain a fuller appreciation of their strengths and weaknesses. The book is organized into nine chapters with over 170 illustrations and 1,200 references. The book provides insight into scientific thought and forms a framework for future enquiry into muscle function.

The author, an emeritus professor in the department of physiology and cell biology at Ohio State University, has been a contributor to research in the muscle field for over forty years.

Essays on the History of Respiratory Physiology

West, John B.

2015, XIV + 342 pp.; 129 illus., 14 illus. in color.

ISBN 978-1-4939-2362-5

Series: Perspectives in Physiology

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  • The book is written for scientists but is accessible to interested non-scientists
  • Covers the history of significant people and events over the whole course of respiratory physiology
  • Discusses how historical events such as the Renaissance and Enlightenment shaped respiratory physiology

This book consists of 23 essays about prominent people and events in the history of respiratory physiology. It provides a first-hand chronicle of the advancements made in respiratory physiology starting with Galen and the beginnings of Western physiology. The volume covers many aspects of the evolution of this important area of knowledge: pulmonary circulation, Boyle’s Law, pulmonary capillaries and alveoli, morphology, gas exchange and blood flow, mechanics, control of ventilation, and comparative physiology. The book emphasizes societal and philosophical aspects of the history of science. Although it concentrates on physiology, it also describes how cultural movements, such as The Enlightenment, shaped the researchers discussed.

The Rise of Fetal and Neonatal Physiology: Basic Science to Clinical Care

Longo, Lawrence D.

2013, XXVII + 533 pp.; 52 illus., 18 illus. in color.

ISBN 978-1-4614-7920-8

Series: Perspectives in Physiology

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  • Constitutes a definitive history of an important field of physiology, that which concerns the developing fetus and newborn infant
  • Addresses the contributions of basic scientists and physiologists to clinical problems of prematurity, such as the causes of premature labor, respiratory distress syndrome, retinopathy of prematurity, and thermoregulation
  • Includes contributions from over 40 leading scientists in this field

During the mid- to late-twentieth century, study of the physiology of the developing fetus and newborn infant evolved rapidly to become a major discipline in the biomedical sciences. Initially of interest from a standpoint of function of the placenta and oxygenation of the fetus, the field advanced to explore both normal functional mechanisms as well as pathophysiologic aspects of their regulation. Examples include studying the role and regulation of circulatory vascular anatomic shunts in oxygenation, cardiac function, certain aspects of asphyxia in the fetus and newborn infant, the role of fetal “breathing” movements, cyclic electroencephalographic activity, and analysis of electronic monitoring of fetal heart rate variability and its significance.

Included in this book are reminisces of several dozen individuals who played a vital role in these developments. Overall, this survey considers a number of aspects of the development of the science of fetal and neonatal physiology, and its role in the greatly improved care of pregnant women and their newborn infants.

Book Monograph Series

The American Physiological Society is devoted to fostering education, scientific research, and dissemination of information in the physiological sciences. The APS publishes three book series, now in partnership with Springer: Perspectives in Physiology (formerly People and Ideas), Methods in Physiology and Physiology in Health and Disease (formerly Clinical Physiology), as well as general titles. For further information about previously published and forthcoming titles, see below.

Perspectives in Physiology

This popular series seeks to place medical science inside a greater historical framework, describing the main pathways of development and highlighting the contributions of prominent investigators.

Methods in Physiology

This series describes experimental techniques in cellular, molecular and general physiology. Each book is edited by experts in their field and covers theory and history behind the method, critical commentary, major applications with examples, limitations and extensions of each technique, and vital future directions.

Physiology in Health and Disease

Your bridge between basic science and clinical medicine. Each book brings together fresh ideas in the study of disease states and crucial physiological function. Each is meticulously edited by leaders in the field it covers.

General Titles

More authoritative titles brought to you by the APS.