William Hansel
Education:
M.S., Cornell University, New York, NY, 1947, Animal Physiology
Ph.D., Cornell University, New York, NY, 1949, Animal Physiology
Research Interests:
Dr. Hansel's major research interests are in cancer, reproductive biology and nutrition. He currently leads a group of scientists at the Pennington Center and on the LSU Campus that is developing a new method for treating prostate, breast, testes, and ovarian cancers based on targeting lytic peptides to gonadotropin receptors on the cancer cell membranes.
Selected Publications:
Leuschner C, Hansel W. Membrane disrupting lytic peptides for cancer treatments. Curr Pharm Des. 2004;10(19):2299-310
Zaleska, M., Waclawik, A., Bodek, G., Zezula-Szpyra, A., Li, X., Janowski, T., Hansel, W.H., Rahman, N.A., and Ziecik, A.J. (2004) Growth repression in diethylstilbestrol/dimethylbenz [a]anthracene-induced rat mammary gland tumor using Hecate-CGb conjugate. Exp. Biol. Med. 229:335-344.
Leuschner, C., Enright, F., Gawronska, B., and Hansel, W. (2003) Membrane disrupting lytic peptide conjugates destroy hormone dependent and independent breast cancer cells in vitro and in vivo. Breast Cancer Research Treat., 78:17-27.
Jaroszewski, J.J., Skarzynski, D.J., Blair, R.M., and Hansel, W. (2003) Influence of nitric oxide on the secretory function of the bovine corpus luteum: dependence on cell composition and cell-to-cell communication. Exp. Biol. Med., 228:741-8.
Bodek, G., Rahman, N. A., Zaleska, M., Soliymani, R., Lankinen, H., Hansel, W., Huhtaniemi, I., and Ziecik, A. J. (2003) A novel approach of targeted ablation of mammary carcinoma cells through luteinizing hormone receptors using Hecate-CGb conjugate. Breast Cancer Res. Treat., 79:1-10.
Skarzynski DJ, Jaroszewski JJ, Bah MM, Deptula KM, Barszczewska B, Gawronska B, Hansel W. Administration of a nitric oxide synthase inhibitor counteracts prostaglandin F2-induced luteolysis in cattle. Biol Reprod. 2003 May;68(5):1674-81. Epub 2002 Nov 27
Hansel W. The potential for improving the growth and development of cultured farm animal oocytes. Anim Reprod Sci. 2003 Dec 15;79(3-4):191-201. Review
Jaroszewski JJ, Skarzynski DJ, Hansel W. Nitric oxide as a local mediator of prostaglandin F2alpha-induced regression in bovine corpus luteum: an in vivo study. Exp Biol Med (Maywood). 2003 Oct;228(9):1057-62
Long R, Steinmetz T, Hommelhoff P, Hansel W, Hansch TW, Reichel J. Magnetic microchip traps and single-atom detection. Philos Transact Ser A Math Phys Eng Sci. 2003 Jul 15;361(1808):1375-89
Leuschner C, Enright FM, Gawronska-Kozak B, Hansel W. Human prostate cancer cells and xenografts are targeted and destroyed through luteinizing hormone releasing hormone receptors. Prostate. 2003 Sep 1;56(4):239-49
Zaleska M, Bodek G, Jana B, Hansel W, Ziecik AJ. Targeted destruction of normal and cancer cells through lutropin/choriogonadotropin receptors using Hecate-betaCG conjugate. Exp Clin Endocrinol Diabetes. 2003 May;111(3):146-53