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The Heme-Heme Oxygenase-Carbon Monoxide System and the Control of
Cardiovascular and Renal Function
APS Cross Sectional Symposium
Alberto Nasjletti and Nader Abraham
N.G. Abraham, R. Wang, M. Perrella, R. Johnson and W. Wang
Heme availability is a determinant of the expression/activity of a large
number of hemoprotein relevant to the control of cardiovascular and renal
functions, e.g., soluable guanylate cyclase, cytochrome P450 oxygenases,
cyclooxygenases, etc. Moreover, products of heme metabolism by heme
oxygenase are known to mediate antioxidative functions (e.g., biliverdin and
bilirubin) and influence vasomotor tone and ion transport (e.g., carbon
monoxide). Accordingly, over the past decade the heme-heme oxygenase-carbon
monoxide system has emerged as an important player in the control of
cardiovascular and renal function in both health and disease. The proposed
symposium will highlight for the first time this emerging area of research
in a meeting of the American Physiological Society. Dr. Nader Abraham will
discuss the regulatory aspects of heme oxygenase expression and carbon
monoxide production, and describe critical interactions with other
vasoregulatory systems, viz., cytochrome P450-derived eicosanoids,
prostaglandins and nitric oxide and cyclic GMP. Dr. Wang will relate the
vasoregulatory actions of carbon monoxide to the stimulation of KCa
channels in vascular smooth muscle. Dr. M. Perella will discuss the
role of heme oxygenase expression in the development of Goldblatt
hypertension and associated renal function disturbances. Dr. R. Johnson
will discuss the role of heme oxygenase-derived carbon monoxide in the
central control of blood pressure and baroreflex function. Dr. W-H Wang
will discuss the role of heme oxygenase-derived carbon monoxide in the
regulation of ion transport activity in the loop of Henle of the kidney and
its impact on renal excretory function. This symposium will highlight an
emerging area of research and will be of interest to APS members in the
renal, cardiovascular and water and electrolyte sections.
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