Use of Mouse Models to Understand the Pathophysiology of Diabetes:
Implications for Preventing Complications
APS Translational Research Group
Derek Le Roith
A. Domenico, B. B. Kahn, C. Ronald Kahn and M. J. Birnhaum
Type 2 diabetes is an extremely common disorder. It is usually
associated with insulin resistance and the multiple metabolic syndrome, the
features of which lead to the commonly seen diabetic complications including
micro-and macro-vascular disease. Recently, much progress in our
understanding of the pathophysiology of the disorder has been made by the
study of genetically manipulated mouse models.
This symposium will present the latest models that have been produced and
their insights into the beta cell dysfunction and insulin resistance; the
two defects found in this disorder. Associated abnormalities that affect
the disease such as glucotoxicity and lipotoxicity will be addressed as well
as the progression to diabetic complications with the emphasis on how
manipulations of these associated conditions can be prevented.
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