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Metalloprotienase and Diabetes
APS Renal Section
Suresh C. Tyagi
M.R. Hayden, S. Tyagi, D. Lovett and Z.Galis
Accumulation of excessive extracellular matrix (ECM)
impairs cardiac muscle contraction and relaxation, vascular distensibility,
and renal function. In particular, the increased matrix accumulation leads
to cardiovascular and renal dysfunction in diabetes, left ventricle
hypertrophy (LVH), and hypertension. It is unclear, however, whether the
matrix accumulation is due to an imbalance between the levels of matrix
metalloproteinases (MMPs) and their target inhibitors (TIMPs). Although MMPs
play a significant role in remodeling the connective tissue in
cardiovascular-renal injury, the role of MMP and TIMPs in excessive matrix
deposition in diabetes, LVH, and hypertension is unclear. It is possible
that during diabetes matrix accumulation between the tubular-interstitium
interferes with salt and water resorption and leads to hypertension. This
comprehensive and translational symposia will focuses on the role of
metalloproteinases in cardiac hypertrophy and fibrosis, vascular remodeling
and glomerular, vascular and tubulointerstitial disease in hypertension and
diabetes. This symposium will assemble the premiere investigators, working
on metalloproteinases in heart, kidney and vessel, together and will impart
on the mechanism of cardiovascular and renal remodeling in diabetes and
hypertension.
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