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Redox Control of Skeletal Muscle Adaptation to Exercise and
Inactivity
APS Environmental & Exercise Physiology Section
Scott Powers and Mike Reid
S.K. Powers, J.G. Tidball, M.B. Reid and M. Jackson
Redox control and inflammatory processes
are important aspects of skeletal muscle biology. Indeed, both redox factors
and cytokines play important roles in many aspects of muscle biology
including regulation of muscle force production and control of gene
expression in response to altered activity patterns and muscle injury. This
symposium will address several key aspects of the role that redox balance
and inflammation play in skeletal muscle adaptation. First, Scott Powers
will provide a tutorial overview of the role that redox balance and
cytokines in skeletal muscle adaptation to increased and decreased
contractile activity. Second, James Tidball will discuss the position of
inflamatory processes in skeletal muscle remodeling during unloading.
Michael Reid will then address the topic of exercise-induced control of
muscle proteolysis involving the ubiquitin-proteasome system. Finally,
Malcolm Jackson will discuss the role of free radicals in skeletal muscle
injury and apoptosis.
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