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A. Clifford Barger Symposium: Control of Blood Flow in the 21st Century-More Questions than Answers
APS Cardiovascular Section
William Chilian
H.M. Goodman, W.M. Chilian, D. Merkus, D.D. Gutterman, R. Busse, C. Zhang and R.J.
Bache
The control of blood flow at the local level is an
enigma: it is essential to the survival of organ systems that depend on a
continual supply of oxygen for function—brain and heart—but in the 21st
Century these regulatory mechanisms are poorly understood. The goal of this
symposium is to gather esteemed scientists who are known for their work on
vascular control, and who study the control of vasomotor tone by using
vertically integrated approaches. Dr. Chilian, one of the session chairs,
will introduce the problem and discuss some of the recent approaches that
are being used to study this problem. Dr. Dr. David Gutterman will present
his work that shows the control of tone in human resistance arteries is not
always best extrapolated from animal studies, and even a response such as
dilation to adenosine is transduced by a different set of signaling
molecules than in animal models. Dr. David Harrison will discuss the role
of oxidant stress in modulating vasoactive reaction in blood vessels, and
will describe experiments using conditional knock-outs to study vasoactive
events. Dr. Rudi Busse will summarize recent work showing the importance of
the cytochrome P450 system in the production of epoxyeicosotrienoic acids,
and how dominant/negative viruses and anti-sense approaches allowed
understanding of this problem. Daphne Merkus will discuss the problem some
vasoactive mechanisms by which parenchymal cells communicate with both
vascular myocytes and the endothelium. Dr. Merkus will discuss factors that
influence the production of constrictors and dilators by cardiac myocytes
and how alterations in the balance of this production impacts significantly
on coronary vasomotor tone. And finally, Dr. Robert Bache will summarize
the content, and discuss how to put together such information into an
integrated scheme. This symposium should draw an audience from the CV
Section, the Microcirculatory Society, NAVBO, and the cardiovascular
interest groups of ASPET. There has not been a symposium dedicated
specifically to vascular control at EB since 1996. In that symposium, the
attendance was over 300 people, and we believe latest insights into vascular
control are an important topic.
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