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Assembly of Tissues: Coordinating Cell Interactions in Large,
Multicellular Systems
Biomedical Engineering Society
Thomas C. Skalak and Robert Tranquillo
S.M. Peirce, R. Tranquillo, M. Krasnow and G.M. Odell
This session will address the interaction of cell-cell and cell-matrix
interactions at the tissue scale. Most tissue assembly and reparative
medicine processes involve multicellular interactions in large aggregates of
thousands of cells. Patterning and eventual function of the tissue system
emerges from the interplay of epigenetic and genetic controls, including
mechanical and biochemical cues. A central problem of the post-genomic and
proteomic era will be to engineer understanding of how local (cellular)
signaling events are integrated into functional tissue assembly. A variety
of methods to develop rational, quantitative models for these processes will
be explored, including computational automata for tissue assembly,
field-based models of cell-matrix traction, diffusible molecular signals
over short and long-range, and cell-cell contact signaling events.
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