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Remodeling of Adult Tissues: Beneficial Adaptation, Disease and the
Engineering of Reparative Medicine
Biomedical Engineering Society
Andrew McCulloch and Rakesh Jain
M. Simons, R. Jain, J. Hubbell and A. McCulloch
This session will explore how integration of the new
knowledge of assembly events at both the molecular scale and multicellular
scale (discussed in Sessions 1 and 2) is producing new understanding of
beneficial remodeling in normal adaptations to environmental stresses, of
disease states, and to harnessing of the adaptive processes for rational
design of reparative medicine strategies. Specific examples will include
therapeutic angiogenesis in the heart (where multicell and multisignal
approaches are now replacing single growth factor strategies), heart
adaptation, neural repair after stroke, and skeletal tissue repair in
ligament and cartilage.
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