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Strategies for the Prevention of Alcohol-Mediated Tissue Injury
American Federation for Medical Research
Michael Hart
Speakers: Speakers: Ali Banan, Lou Ann Brown, David Guidot, C. Michael
Hart, Joe Sisson
Although chronic alcohol ingestion injures specific target tissues
including the liver, recent evidence demonstrates that chronic alcohol
ingestion also predisposes non-traditional tissue targets such as the lung
and intestinal epithelium to injury. Chronic alcohol ingestion predisposes
to lung injury through alterations in pulmonary epithelial and endothelial
function. Chronic alcohol ingestion perturbs gut epithelial function by
similar mechanisms. The presenters in this symposium will highlight recent
advances in the understanding of mechanisms by which chronic alcohol
ingestion mediates epithelial and endothelial cell dysfunction in vitro and
in vivo. The roles of alcohol-induced depletion of cellular glutathione,
stimulation of reactive species, and activation of angiotensin II and
transforming growth factor beta signaling will be discussed. Finally,
clinically relevant strategies that prevent tissue and organ dysfunction
will be reviewed, and the potential for these interventions as future
strategies in the prevention or treatment of alcohol-related disease will be
discussed.
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