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President’s Symposium: Live Cell Imaging of the Microcirculation: New Frontiers for Intravital Microscopy
Sponsored by The Microcirculatory Society
 

Our goal is to present state-of-the art research across integrative disciplines that focus on understanding cellular signaling at the level of the microcirculation in the broad context of tissue structure and its functional integrity. During this symposium, each speaker will give a 25-30 minute presentation of their research findings based upon imaging the living microcirculation and associated signaling events in intact tissues. Dr. Balaban will begin by exploring the nature of coupling between striated muscle metabolism and blood flow, with an emphasis on mitochondrial energetics and intracellular calcium signaling. Dr. Iadecola will follow by considering cellular mechanisms that increase cerebral blood flow in response to neural activity and how these relationships are altered in brain diseases, including Alzheimer’s. Dr. Mcgavern will continue by discussing a novel mode of immune pathogenesis during viral meningitis as defined by massive recruitment of leukocytes. Dr. Dickinson will conclude this session by discussing cellular signaling events that are elicited by blood flow and are required for proper vessel development. Each presentation will be followed by 5-10 minutes of discussion. Dr. Segal will give brief introductions for respective sessions and mediate the ensuing questions and discussion.