Newly-Emerging Signaling Pathways in the Renal Microcirculation
Sponsored by APS Renal Section
Cell Signaling Track

 SEQ CHAPTER \h \r 1This symposium will focus on some of the newer concepts concerning the regulation of the renal microcirculation, highlighting the work of emerging leaders in the field. The vascular smooth muscle mechanisms encountered within the various segments of the renal vascular bed exhibit an unusual level of heterogeneity and although vascular interactions between neighboring nephrons are quite apparent, we are only beginning to understand the molecular basis of microvascular communication within the kidney. Dr. Hansen will present an update on the diversity of smooth muscle calcium channels found in pre- and post-glomerular resistance vessels.  Dr. Takenaka will present recent work on the renal microvascular distribution of connexins and on their involvement in renal vascular regulation and communication along the renal microvascular network.  Dr. Li will update us on our current understanding of the role of cyclic ADP-ribose in smooth muscle and will discuss the involvement of this novel signaling pathway in the renal vasculature. The renal myogenic response plays a major role in renal autoregulation and renal protection, but the underlying mechanisms are poorly understood. Dr. Yip’s presentation will address the role of integrins in Ca signaling in the afferent arteriole and the involvement of this pathway in the myogenic response of this vessel.